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|Title:||Method for treating T-cell lymphoblastic leukemia with ara-G nucleoside derivatives|
|Abstract:||6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.|
|Inventor(s):||Krenitsky; Thomas A. (Chapel Hill, NC), Averett; Devron R. (Raleigh, NC), Koszalka; George W. (Chapel Hill, NC), Wolberg; Gerald (Cary, NC)|
|Assignee:||Burroughs Wellcome Co. (141) (Research Triangle Park, NC)|
1. A method of treating T-cell lymphoblastic leukemia in a mammal having T-cell lymphoblastic leukemia which comprises administering to said mammal an effective T-cell lymphoblastic
leukemia treatment amount of the compound 9-.beta.-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine.
2. A method of treating T-cell lymphoblastic leukemia in a mammal having T-cell lymphoblastic leukemia which comprises administering to said mammal an effective leukemia treatment amount of the compound 9-.beta.-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 in which the compound is administered by injection.
4. The method of claim 2 in which the compound or salt thereof is administered by injection.
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