Claims for Patent: 5,478,847

Summary for Patent: 5,478,847

Title:	Methods of use for inhibiting bone loss and lowering serum cholesterol
Abstract:	A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s):	Draper; Michael W. (Carmel, IN)
Assignee:	Eli Lilly and Company (Indianapolis, IN)
Application Number:	08/205,012
Patent Claims:	1. A method of inhibiting bone loss or bone resorption comprising administering to a human in need thereof a compound of formula I ##STR3## or a pharmaceutically acceptable salt or solvate thereof, in an amount of about 50 to 150 mg/day. 2. A method of claim 1 wherein the human has been diagnosed as suffering from osteoporosis. 3. A method of claim 1 wherein the human is a post-menopausal female. 4. A method of claim 1 wherein the human is a male. 5. A method of claim 1 wherein the compound is administered prophylactically. 6. A method of claim 1 wherein the compound of formula I is administered in an amount of about 60 to about 150 mg/day. 7. A method of claim 1 wherein the compound of formula I is administered in an amount of 60 mg/day. 8. A method of claim 1 wherein the compound of formula I is administered in an amount of 75 mg/day. 9. A method of claim 1 wherein the compound of formula I is administered in an amount of 100 mg/day. 10. A method of claim 1 wherein the compound of formula I is administered in an amount of 125 mg/day. 11. A method of claim 1 wherein the compound of formula I is administered in an amount of 150 mg/day. 12. A method of claim 1 wherein the compound is the hydrochloride salt.