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Claims for Patent: 5,470,567

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Claims for Patent: 5,470,567

Title: Synergistic skin depigmentation composition
Abstract:There is disclosed a synergistic composition and process for skin depigmentation with reduced irritation which does not employ a corticosteroid and which employs a substituted oxybenzene and a retinoid.
Inventor(s): Nair; Xina (E. Amherst, NY), Tramposch; Kenneth M. (Williamsville, NY)
Assignee: Bristol Myers Squibb Company (New York, NY)
Application Number:08/141,503
Patent Claims: 1. A synergistic composition for skin depigmentation free of corticosteroid comprising:

(a) 4-hydroxyanisole in an amount from about 0.1% to about 2% by weight;

(b) a retinoid selected from the group consisting of all-trans retinoic acid in an amount from about 0.001% to about 0.1% by weight, (N-acetyl-4-aminophenyl) retinoate in an amount from about 0.001% to about 0.01%, and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in an amount from about 0.001% to about 0.1% by weight; and

(c) a dermatologically acceptable carrier.

2. The composition of claim 1 comprising from about 1% to about 2% of 4-hydroxyanisole and from about 0.01% to about 0.1% of all-trans retinoic acid.

3. The composition of claim 1 comprising from about 1% to about 2% of 4-hydroxyanisole and from about 0.001% to about 0.01% of (N-acetyl-4-aminophenyl) retinoate.

4. The composition of claim 1 comprising from about 1% to about 2% of 4-hydroxyanisole and from about 0.01% to about 0.1% of 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

5. A method for skin depigmentation which comprises topically applying to the skin a synergistic composition free of corticosteroid which comprises:

(a) 4-hydroxyanisole in an amount from about 0.1% to about 2% by weight;

(b) a retinoid selected from the group consisting of all-trans retinoic acid in an amount from about 0.001% to about 0.1% by weight, (N-acetyl-4-amino-phenyl) retinoate in an amount from about 0.001% to about 0.01% by weight and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in an amount from about 0.001% to about 0.1% by weight; and

(c) a dermatologically acceptable carrier.

6. The method of claim 5 wherein the composition comprises from about 1% to about 2% of 4-hydroxyanisole and from about 0.01% to about 0.1% of all-trans retinoic acid.

7. The method of claim 5 wherein the composition comprises from about 1% to about 2% of 4-hydroxyanisole and from about 0.001% to about 0.01% of (N-acetyl-4-aminophenyl) retinoate.

8. The method of claim 5 wherein the composition comprises from about 1% to about 2% of 4-hydroxyanisole and from about 0.01% to about 0.1% of 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.
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