Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
McKesson
Johnson and Johnson
UBS
Boehringer Ingelheim
US Army
Cipla
Express Scripts
Merck

Generated: April 20, 2018

DrugPatentWatch Database Preview

Claims for Patent: 5,466,699

« Back to Dashboard

Summary for Patent: 5,466,699
Title: Indolyl compounds for treating migraine
Abstract:
Inventor(s): Robertson; Alan D. (Beckenham, GB2), Hill; Alan P. (Beckenham, GB2), Glen; Robert C. (Beckenham, GB2), Martin; Graeme R. (Beckenham, GB2)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:08/341,206
Patent Claims: 1. A compound of formula (I) ##STR37## wherein n is an integer of from 0 to 3;

W is a group of formula (i), (ii), or (iii) ##STR38## wherein R is hydrogen or C.sub.1-4 alkyl, X is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral center * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and

Z is a group of formula (iv) or (vi) ##STR39## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl and R.sup.3 is hydrogen or C.sub.1-4 alkyl; or a physiologically acceptable salt or solvate thereof.

2. A compound of formula (I) according to claim 1, wherein n is 1 or W is a group of formula (i).

3. A compound of formula (I) according to claim 1 wherein n is 1, W is a group of formula (i) wherein R is hydrogen, X is --O-- and Y is oxygen, and Z is a group of formula (iv) or (vi) wherein R.sup.1 =R.sup.2 =hydrogen or methyl.

4. A compound of formula (I) as claimed in claim 1, which compound is N,N-dimethyl-2-[5-2-oxo-1,3-oxazolidin-4-ylmethyl)-1H-indole -3-yl]ethylamine or 3-(1-methyl-4-piperidyl)-5-(2-oxo-1,3-oxazolidin-4-ylmethyl) 1-H-indole in either its (S) or (R) form or as a mixture thereof in any proportions.

5. A method of treating or preventing migraine comprising administering to a patient in need of same an effective amount of a compound of claim 1.

6. A pharmaceutical composition comprising an effective amount of a compound of formula (I) as claimed in claim 1 with a pharmaceutically acceptable carrier.

7. The pharmaceutical composition of claim 6 which is in the form of a tablet or capsule.

8. The compound (S)-N,N-dimethyl-2-[5-(2-oxo-1,3-oxazolidin -4-ylmethyl)-1H-indole-3-yl]ethylamine or a pharmacologically acceptable salt or solvate thereof.

9. A method of treating or preventing migraine comprising administering to a patient in need of same an effective amount of a compound of claim 8.

10. A pharmaceutical composition comprising an effective amount of a compound of claim 8 with a pharmaceutically acceptable carrier.

11. The pharmaceutical composition of claim 10 which is in the form of a tablet or capsule.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
Merck
Federal Trade Commission
Citi
Fuji
AstraZeneca
Argus Health
Moodys
QuintilesIMS

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.