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Claims for Patent: 5,466,699

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Claims for Patent: 5,466,699

Title: Indolyl compounds for treating migraine
Abstract:
Inventor(s): Robertson; Alan D. (Beckenham, GB2), Hill; Alan P. (Beckenham, GB2), Glen; Robert C. (Beckenham, GB2), Martin; Graeme R. (Beckenham, GB2)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:08/341,206
Patent Claims: 1. A compound of formula (I) ##STR37## wherein n is an integer of from 0 to 3;

W is a group of formula (i), (ii), or (iii) ##STR38## wherein R is hydrogen or C.sub.1-4 alkyl, X is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral center * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and

Z is a group of formula (iv) or (vi) ##STR39## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl and R.sup.3 is hydrogen or C.sub.1-4 alkyl; or a physiologically acceptable salt or solvate thereof.

2. A compound of formula (I) according to claim 1, wherein n is 1 or W is a group of formula (i).

3. A compound of formula (I) according to claim 1 wherein n is 1, W is a group of formula (i) wherein R is hydrogen, X is --O-- and Y is oxygen, and Z is a group of formula (iv) or (vi) wherein R.sup.1 =R.sup.2 =hydrogen or methyl.

4. A compound of formula (I) as claimed in claim 1, which compound is N,N-dimethyl-2-[5-2-oxo-1,3-oxazolidin-4-ylmethyl)-1H-indole -3-yl]ethylamine or 3-(1-methyl-4-piperidyl)-5-(2-oxo-1,3-oxazolidin-4-ylmethyl) 1-H-indole in either its (S) or (R) form or as a mixture thereof in any proportions.

5. A method of treating or preventing migraine comprising administering to a patient in need of same an effective amount of a compound of claim 1.

6. A pharmaceutical composition comprising an effective amount of a compound of formula (I) as claimed in claim 1 with a pharmaceutically acceptable carrier.

7. The pharmaceutical composition of claim 6 which is in the form of a tablet or capsule.

8. The compound (S)-N,N-dimethyl-2-[5-(2-oxo-1,3-oxazolidin -4-ylmethyl)-1H-indole-3-yl]ethylamine or a pharmacologically acceptable salt or solvate thereof.

9. A method of treating or preventing migraine comprising administering to a patient in need of same an effective amount of a compound of claim 8.

10. A pharmaceutical composition comprising an effective amount of a compound of claim 8 with a pharmaceutically acceptable carrier.

11. The pharmaceutical composition of claim 10 which is in the form of a tablet or capsule.
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