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Claims for Patent: 5,466,446

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Claims for Patent: 5,466,446

Title: Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof
Abstract:Dermatological conditions are treated by topically applying to the affected area an effective amount of a combination benzoyl peroxide and clindamycin composition.
Inventor(s): Stiefel; Werner K. (Coral Gables, FL), Popp; Karl F. (Schodack Landing, NY)
Assignee: Stiefel Laboratories, Inc. (Coral Gables, FL)
Application Number:08/197,076
Patent Claims: 1. A topical gel composition for treating skin disorders involving the sebaceous glands and follicles in humans, said composition consisting essentially of an effective amount of a mixture of: (i) at least 4.5% by weight of benzoyl peroxide, and (ii) at least 0.9% by weight of clindamycin, admixed with a topically acceptable pharmaceutical carrier consisting essentially of about 0.04% disodium monolaurel sulfosuccinate, about 2.0% of a carbomer, about 0.1% of disodium ethylene diaminetetraacetic acid, about 0.1% of dimethicone, about 0.25% of hydrated silica, about 0.20% of poloxamer 182 and about 0.31% of sodium hydroxide by weight of said composition, wherein the composition is stable for at least 3 months at ambient temperature.

2. A method for treating skin disorders involving the sebaceous glands and follicles in humans which consists essentially of topically applying to affected skin an effective amount of a mixture of at least 4.5% by weight of benzoyl peroxide and at least 0.9% by weight of clindamycin admixed with a topically acceptable pharmaceutical carrier in gel form, consisting essentially of about 0.04% disodium monolaurel sulfosuccinate, about 2.0% of a carbomer, about 0.1% of disodium ethylene diaminetetraacetic acid, about 0.1% of dimethicone, about 0.25% of hydrated silica, about 0.20% of poloxamer 182 and about 0.31% of sodium hydroxide by weight of said composition.
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