|Title:|| Medicament to combat autoimmune diseases|
|Abstract:||A pharmaceutical composition for use in the treatment of chronic Graft-versus-host diseases as well as autoimmune diseases, in particular for the treatment of systemic lupus erythematosus containing as an active ingredient at least one compound of the formulae 1 or 2 ##STR1## the latter being present per se or in the form of a physiologically tolerable salt. The invention also relates to a dosage unit form of said pharmaceutical composition and a method of treating chronic Graft-versus host diseases as well as autoimmune diseases, in particular systemic lupus erythematosus.|
|Inventor(s):|| Bartlett; Robert R. (Darmstadt, DE), Schleyerbach; Rudolph (Hofheim am Taunus, DE), Kammerer; Friedrich-Johannes (Hochheim am Main, DE) |
|Assignee:|| Hoechst Aktiengesellschaft (Frankfurt, DE) |
1. A composition comprising N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide having the formula: ##STR2## and a pharmaceutically acceptable carrier.