|Title:||Method for treating neurological disorders|
|Abstract:||A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.|
|Inventor(s):||Kim; Sinil (Solana Beach, CA), Howell; Stephen B. (Del Mar, CA)|
|Assignee:||DepoTech Corporation (LaJolla, CA)|
1. A method for ameliorating a cell proliferative disease which comprises intralumbar administration to the cerebrospinal fluid (CSF) of a human with the disease of a therapeutically
effective amount of an antitumor drug in a synthetic membrane vesicle such that the antitumor agent persists in the cerebro-ventricular space for a time sufficient to ameliorate the disease.
2. The method of claim 1, wherein the synthetic membrane vesicle is a liposome.
3. The method of claim 2, wherein the liposome contains multiple concentric chambers.
4. The method of claim 1, wherein the synthetic membrane vesicle contains multiple non-concentric chambers.