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Claims for Patent: 5,441,958

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Claims for Patent: 5,441,958

Title: Ophthalmic compositions comprising emedastine and methods for their use
Abstract:Topical ophthalmic compositions comprising 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts have been found to be useful in treating allergic conjunctivitis and related ailments.
Inventor(s): Yanni; John M. (Burleson, TX), Robertson; Stella M. (Arlington, TX), Okumura; Shigetoshi (Nara, JP), Tanaka; Hitoshi (Nara, JP), Saito; Tadayuki (Osaka, JP)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Application Number:08/163,973
Patent Claims: 1. A method for treating allergic conjuctivitis, comprising topically administering to an affected eye an antihistaminic effective amount of a compound selected from the group consisting of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts.

2. The method of claim 1, wherein said compound is present at a concentration between about 0.0001 and about 1.0 wt %.

3. The method of claim 2, wherein said compound is present at a concentration between about 0.005 and about 0.2 wt %.

4. The method of claim 3, wherein said compound is present at a concentration between about 0.05 and about 0.2 wt %.

5. The method of claim 1, wherein the compound comprises the difumarate salt of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole.
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