Last Updated: May 10, 2026

Claims for Patent: 5,424,286

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Summary for Patent: 5,424,286

Title:	Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
Abstract:	This invention encompasses pharmaceutical compositions containing exendin-3 or exendin-4, fragments thereof, or any combination thereof, and methods for the treatment of diabetes mellitus and the prevention of hyperglycemia.
Inventor(s):	John Eng
Assignee:	Individual
Application Number:	US08/066,480
Patent Claims:	1. A polypeptide having the amino acid sequence:HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG P[SEQ ID No:3]. 2. A polypeptide having the amino acid sequence:HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG Y[SEQ ID No:4]. 3. A pharmaceutical composition which comprises an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence of claim 1 in a suitable carrier, which will stimulate the secretion of insulin in vivo. 4. A pharmaceutical composition which comprises an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified form natural sources, having the amino acid sequence of claim 2 in a suitable carrier, which will stimulate the secretion of insulin in vivo. 5. A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence: HSDGTFITSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO: 1), wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1. 6. A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence: HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO: 2), wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1. 7. A method of inhibiting insulin release in a mammal comprising administering an effective amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence: DL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO: 5).

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