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Claims for Patent: 5,424,286

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Claims for Patent: 5,424,286

Title: Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
Abstract:This invention encompasses pharmaceutical compositions containing exendin-3 or exendin-4, fragments thereof, or any combination thereof, and methods for the treatment of diabetes mellitus and the prevention of hyperglycemia.
Inventor(s): Eng; John (Bronx, NY)
Assignee:
Application Number:08/066,480
Patent Claims: 1. A polypeptide having the amino acid sequence:

HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG P[SEQ ID No:3].

2. A polypeptide having the amino acid sequence:

HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG Y[SEQ ID No:4].

3. A pharmaceutical composition which comprises an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence of claim 1 in a suitable carrier, which will stimulate the secretion of insulin in vivo.

4. A pharmaceutical composition which comprises an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified form natural sources, having the amino acid sequence of claim 2 in a suitable carrier, which will stimulate the secretion of insulin in vivo.

5. A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:

wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1.

6. A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:

wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1.

7. A method of inhibiting insulin release in a mammal comprising administering an effective amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:
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