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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Fish and Richardson
US Department of Justice
Daiichi Sankyo
US Army

Generated: May 24, 2018

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Claims for Patent: 5,412,095

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Summary for Patent: 5,412,095
Title: Terazosin monohydrochloride and processes and intermediate for its production
Abstract:The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.
Inventor(s): Morley; James A. (Gurnee, IL), Bauer; John F. (Lake Bluff, IL), Patel; Ramesh F. (Chicago, IL), Henry; Rodger E. (Waukegan, IL), Spanton; Stephen G. (Grayslake, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:08/246,526
Patent Claims: 1. The compound having the name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate characterized by peaks in the powder x-ray diffraction pattern at values of two theta of 5.09.degree.35 0.2.degree.; 9.63.degree..+-.0.2.degree.; 11.64.degree..+-.0.2.degree.; 15.32.degree..+-.0.2.degree.; 16.63.degree..+-.0.2.degree.; 21.25.degree..+-.0.2.degree.; 22.24.degree..+-.0.2.degree.; 22.28.degree..+-.0.2.degree.; 26.62.degree..+-.0.2.degree.; and 28.93.degree..+-.0.2.degree..

2. The non-solvated crystalline polymorph of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride characterized by peaks in the powder x-ray diffraction pattern at values of two theta of 7.29.degree..+-.0.2.degree.; 11.81.degree..+-.0.2.degree.; 14.59.degree..+-.0.2.degree.; 19.43.degree..+-.0.2.degree.; 20.40.degree..+-.0.2.degree.; 21.61.degree..+-.0.2.degree.; 22.36.degree..+-.0.2.degree.; 23.69.degree..+-.0.2.degree.; 24.34.degree..+-.0.2.degree.; 24.80.degree..+-.0.20.degree.; 25.75.degree..+-.0.2.degree.; 27.29.degree..+-.0.2.degree.; 29.96.degree..+-.0.2.degree.; and 31.20.degree..+-.0.2.degree..

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
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Chinese Patent Office

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