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|Title:||Terazosin monohydrochloride and processes and intermediate for its production|
|Abstract:||The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.|
|Inventor(s):||Morley; James A. (Gurnee, IL), Bauer; John F. (Lake Bluff, IL), Patel; Ramesh F. (Chicago, IL), Henry; Rodger E. (Waukegan, IL), Spanton; Stephen G. (Grayslake, IL)|
|Assignee:||Abbott Laboratories (Abbott Park, IL)|
1. The compound having the name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate characterized by peaks in the powder x-ray
diffraction pattern at values of two theta of 5.09.degree.35 0.2.degree.; 9.63.degree..+-.0.2.degree.; 11.64.degree..+-.0.2.degree.; 15.32.degree..+-.0.2.degree.; 16.63.degree..+-.0.2.degree.; 21.25.degree..+-.0.2.degree.;
22.24.degree..+-.0.2.degree.; 22.28.degree..+-.0.2.degree.; 26.62.degree..+-.0.2.degree.; and 28.93.degree..+-.0.2.degree..
2. The non-solvated crystalline polymorph of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride characterized by peaks in the powder x-ray diffraction pattern at values of two theta of 7.29.degree..+-.0.2.degree.; 11.81.degree..+-.0.2.degree.; 14.59.degree..+-.0.2.degree.; 19.43.degree..+-.0.2.degree.; 20.40.degree..+-.0.2.degree.; 21.61.degree..+-.0.2.degree.; 22.36.degree..+-.0.2.degree.; 23.69.degree..+-.0.2.degree.; 24.34.degree..+-.0.2.degree.; 24.80.degree..+-.0.20.degree.; 25.75.degree..+-.0.2.degree.; 27.29.degree..+-.0.2.degree.; 29.96.degree..+-.0.2.degree.; and 31.20.degree..+-.0.2.degree..
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