.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 5,403,858

« Back to Dashboard

Claims for Patent: 5,403,858

Title: New compositions containing taxane derivatives
Abstract:Compositions containing taxane derivatives, consist of a solution of such derivative in a surfactant consisting of polysorbate, polyethelene glycol or hydrogenated castor oil. These compositions can be used to prepare perfusion solutions essentially free of ethanol.
Inventor(s): Bastard; Jean-Pierre (Lesigny, FR), Dupechez; Thierry (Villemoisson sur Orge, FR), Fabre; Jean-Louis (Paris, FR)
Assignee: Rhone-Poulenc Rorer, S.A. (Antony, FR)
Application Number:07/930,392
Patent Claims: 1. A composition consisting essentially of a compound of formula: ##STR2## in which R represents a hydrogen atom or an acetyl radical and R.sub.1 represents a tert-butoxycarbonylamino or benzoylamino radical, dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, and essentially free of ethanol.

2. A composition according to claim 1, which contains less than 5% by volume of ethanol.

3. A composition according to claim 1, wherein, in the compound of formula (I), R represents hydrogen and R.sub.1 represents a tert-butoxycarbonylamino radical.

4. A composition according to claim 1, wherein, in the compound of formula (I), R represents an acetyl group and R.sub.1 represents a benzoyloxyamino radical.

5. A composition according to claim 1, which contains up to 200 mg/ml of compound of formula (I).

6. A composition according to claim 3, which contains 20 to 80 mg/ml of compound of formula (I).

7. A composition according to claim 4, which contains 6 to 20 mg/ml of compound of formula (I).

8. A composition according to claim 2, wherein the composition contains less than 2% of ethanol.

9. A composition according to claim 5, which contains up to 80 mg/ml of compound of formula (I).

10. Composition consisting essentially of a taxane derivative of the formula: ##STR3## in which R represents a hydrogen atom or an acetyl radical and R.sub.1 represents a tert-butoxycarbonylamino or benzoylamino radical dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, said composition containing less than 5% by volume ethanol.

11. Composition according to claim 10, wherein ethanol is less than 2% by volume.

12. A perfusion comprising less than 0.5 mg/ml of compound as defined in claim 3 and less than 1 ml/l of ethanol and less than 15 ml/l of surfactant.

13. A perfusion, comprising 1 mg/ml or less of compound as defined in claim 4 and less than 1 ml/l of ethanol.

14. A perfusion according to claim 12, wherein the perfusion contains 0.1 to 0.3 mg/ml of a compound of formula (I) wherein R represents hydrogen and R.sub.1 represents a tert-butoxycarbonylamino radical.

15. A method for preparing a composition according to claim 1, which comprises dissolving a compound of formula (I) in ethanol, adding the surfactant and removing the ethanol.

16. A method for preparing a composition according to claim 1, which comprises slowly adding a compound of formula (I) to a solution of the surfactant containing 1 to 2% by volume of ethanol.

17. A method for preparing a composition according to claim 15, wherein ethanol is removed by evaporation.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc