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Serving 500+ biopharmaceutical companies globally:

Boehringer Ingelheim
Covington
Medtronic
Queensland Health
Mallinckrodt
Cerilliant
QuintilesIMS
Johnson and Johnson
Cipla
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Generated: July 22, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,384,310

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Claims for Patent: 5,384,310

Title: 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
Abstract:The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.
Inventor(s): Montgomery; John A. (Birmingham, AL), Secrist, III; John A. (Birmingham, AL)
Assignee: Southern Research Institute (Birmingham, AL)
Application Number:07/693,646
Patent Claims: 1. A pharmaceutical composition comprising a compound of the formula ##STR6## wherein R, each which may be the same or different, is hydrogen or a protecting group; wherein Z is a halogen of the group F, Cl, and Br; and pharmaceutically acceptable salts thereof, said composition being in combination with a pharmaceutically acceptable carrier for oral, topical, or parenteral administration.

2. A pharmaceutical composition according to claim 1 wherein R is a protecting group.

3. A pharmaceutical composition according to claim 1 wherein R is hydrogen.

4. A pharmaceutical composition according to claims 1, 2 or 3 wherein Z is Cl.

5. A pharmaceutical composition according to claim 1 wherein the compound is 2-Chloro-9-(2-deoxy-2-fluoro-.beta.-D arabinofuranosyl)-9H-purin-6-amine.

6. A purine nucleoside having the formula ##STR7## wherein R, each which may be the same or different, is hydrogen or a protecting group; wherein Z is a halogen of the group F, Cl, and Br; and pharmaceutically acceptable salts thereof.

7. A purine nucleoside according to claim 6 wherein R is hydrogen.

8. A purine nucleoside according to claim 6 wherein R is a protecting group.

9. A purine nucleoside according to claims 6, 7 or 8 wherein Z is Cl.

10. A purine nucleoside according to claim 6 which is 2-Chloro-9-(2-deoxy-2-fluoro-.beta.-D arabinofuranosyl)-9H-purin-6-amine.
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Serving 500+ biopharmaceutical companies globally:

Accenture
US Army
Medtronic
Daiichi Sankyo
Colorcon
Federal Trade Commission
Boehringer Ingelheim
Farmers Insurance
QuintilesIMS
Julphar

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