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Claims for Patent: 5,362,475

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Claims for Patent: 5,362,475

Title: Gadolinium chelates for magnetic resonance imaging
Abstract:A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
Inventor(s): Gries; Heinz (Berlin, DE), Rosenberg; Douwe (Berlin, DE), Weinmann; Hanns-Joachim (Berlin, DE), Speck; Ulrich (Berlin, DE), Mutzel; Wolfgang (Berlin, DE), Hoyer; Georg-Alexander (Berlin, DE), Pfeiffer, deceased; Heinrich (late of Berlin, DE), Renneke; Franz-Josef (Berlin, DE)
Assignee: Schering Aktiengesellschaft (Berlin, DE)
Application Number:07/911,800
Patent Claims: 1. The di-N-methylglucamine salt of the gadolinium (III) complex of diethylene-triaminepentaacetic acid.

2. The di-N-methylglucamine salt of the gadolinium(III) chelate complex of diethylenetriaminepentaacetic acid in sterile form.

3. Isolated di-N-methylglucamine salt of the gadolinium(III) chelate complex of diethylenetriaminepentaacetic acid.

4. A chelate complex of gadolinium(III) or a salt thereof, wherein said chelate complex or salt is in sterile form and said gadolinium does not emit ionizing radiation.

5. A compound according to claim 4, wherein said compound is a salt of gadolinium diethylenetriaminepentaacetic acid.

6. A compound according to claim 5, wherein said compound is a sodium, glucamine, N-methylglucamine, N,N-dimethylglucamine, ethanolamine, diethanolamine, morpholine, lysine, ornithine or arginine salt of gadolinium diethylenetraiminepentaacetic acid.

7. A compound according to claim 4, wherein said compound is the di-lysine salt of gadolinium diethylenetriaminepentaacetic acid.

8. A compound according to claim 6, wherein said compound is a sodium salt of gadolinium diethylenetriaminepentaacetic acid.

9. A chelate complex of gadolinium(III) or a salt thereof, wherein said chelate complex or salt is in sterile form and said gadolinium is not a radionuclide.

10. A chelate complex of gadolinium(III) or a salt thereof, wherein said chelate complex or salt is in sterile form and said chelate complex or salt is not radioactive.
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