Claims for Patent: 5,360,817

Summary for Patent: 5,360,817

Title:	Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents
Abstract:	PCT No. PCT/AU91/00161 Sec. 371 Date Nov. 10, 1992 Sec. 102(e) Date Nov. 10, 1992 PCT Filed Apr. 24, 1991 PCT Pub. No. WO91/16320 PCT Pub. Date Oct. 31, 1991.Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation .and their use in the treatment of viral infections, in particular influenza, are described.
Inventor(s):	Laurence M. von Izstein, Wen-Yang Wu, Tho V. Phan, Basil Danylec, Betty Jin
Assignee:	Biota Scientific Management Pty Ltd
Application Number:	US07/946,327
Patent Claims:	1. A compound of formula (Ib) ##STR22## wherein R3b is (alk)x NR6b R7b, CN or N3 ; where alk is an unsubstituted or substituted methylene;x is 0 or 1; R6b is hydrogen, C1-6 alkyl, aryl, aralkyl, amidine, NR7b R8b or an unsaturated or saturated ring containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur; R7b is hydrogen, C1-6 alkyl, or allyl; R8b is hydrogen or C1-6 alkyl; and R4b is NNHCOR9b where R9b is hydrogen, substituted or unsubstituted C1-4 alkyl or aryl; or a pharmaceutically acceptable salt or derivative thereof. 2. A compound as claimed in claim 1 wherein R3b is NH2 or NHC(═NH)NH2 . 3. 5-acetamido-4-amino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid and pharmaceutically acceptable salts and derivatives thereof. 4. Sodium 5-acetamido-4-amino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonate. 5. 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid and pharmaceutically acceptable salts and derivatives thereof. 6. Ammonium 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonate. 7. A pharmaceutical formulation comprising a compound as claimed in claim 1 as active ingredient together with a pharmaceutically acceptable carrier therefor. 8. A pharmaceutical formulation suitable for intranasal administration comprising a compound as claimed in claim 1 as active ingredient together with a pharmaceutically acceptable carrier therefor. 9. A pharmaceutical formulation as claimed in claim 7 wherein the active ingredient is 5-acetamido-4-amino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid or a pharmaceutically acceptable salt thereof. 10. A pharmaceutical formulation as claimed in claim 7 wherein the active ingredient is 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid or a pharmaceutically acceptable salt thereof.