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Generated: November 18, 2017

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Claims for Patent: 5,349,085

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Claims for Patent: 5,349,085

Title: X-ray contrast agents
Abstract:Compounds of the general formula: ##STR1## (where R is a group --CH(CH.sub.2 OH).sub.2 or --CH.sub.2 CH(OH)CH.sub.2 OH and A is a group --CH.sub.2 CH(OH)CH.sub.2 -- or --CH.sub.2 CH(OH)CH(OH)CH.sub.2 --) possess a package of favourable parameters which render them of particular use not only in all forms of intravascular visualisation but also in myelography. The compounds are prepared by reaction of an appropriate 5-acetylamino-N,N'-bis(hydroxypropyl)-2,4,6-triiodoisophthalamide with an agent effective to introduce the appropriate hydroxyalkylene group such as for example epichlorohydrin or 1,4-dichloro-2,3-dihydroxybutane.
Inventor(s): Hansen; Per-Egil (Dalbo, NO), Holtermann; Hugo (Hovik, Baerum, NO), Wille; Knut (Oster.ang.s, NO)
Assignee: Nycomed Imaging AS (Oslo, NO)
Application Number:07/960,231
Patent Claims: 1. 1,3-bi s(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-tri iodophenyl]-2-hydroxypropane.
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