You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 19, 2024

Claims for Patent: 5,344,932

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 5,344,932

Title:	N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives
Abstract:	N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]-pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-{4-hydroxy-6-aminopyrrolo-[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-g lutamic acid.
Inventor(s):	Taylor; Edward C. (Princeton, NJ)
Assignee:	Trustees of Princeton University (Princeton, NJ)
Application Number:	07/674,541
Patent Claims:	1. A compound of the formula: ##STR14## in which: R.sup.1 is --OH or --NH.sub.2 ; R.sup.2 is hydrogen or a pharmaceutically acceptable cation: R.sup.3 is 1,4-phenylene unsubstituted or substituted with chloro, fluoro, methyl, methoxy, or trifluoromethyl; R.sup.4 is hydrogen, or methyl; R.sup.5 is amino; and the configuration about the carbon atom designated * is S. 2. A compound according to claim 1 wherein R.sup.1 is --OH; R.sup.3 is 1,4-phenylene, and R.sup.4 is hydrogen. 3. The compound according to claim 1 which is N-{4-[2-(4-hydroxy-6-aminopyrrolo[2,3-d]pyrimidin-3-yl)ethyl]benzoyl}-L-gl utamic acid. 4. The compound according to claim 1 which is N-{4-[1-hydroxy-3-(4-hydroxy-6-aminopyrrolo[2,3-d]pyrimidin-3-yl)prop-2-yl ]benzoyl}glutamic acid. 5. The compound according to claim 1 which is N-{2-fluoro-4-[2-(4-hydroxy-6-aminopyrrolo[2,3-d]pyrimidin-3-yl)ethyl]benz oyl}-L-glutamic acid. 6. The compound according to claim 1 which is N-{3-fluoro-4-[2-(4-hydroxy-6-aminopyrrolo[2,3-d]pyrimidin-3-yl)ethyl]benz oyl}-L-glutamic acid. 7. A compound of the formula: ##STR15## in which: R.sup.1 is --OH or --NH.sub.2 ; R.sup.2' is hydrogen, a pharmaceutically acceptable cation, or a carboxy protecting group: R.sup.3 is 1,4-phenylene unsubstituted or substituted with chloro, fluoro, methyl, methoxy, or trifluoromethyl; R.sup.4' is hydrogen, or methyl; R.sup.5' is amino or amino substituted with an amino protecting group; and the configuration about the carbon atom designated * is S.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.