DrugPatentWatch Database Preview
« Back to Dashboard
Summary for Patent: 5,320,855
|Title:||Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets|
|Abstract:||Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone, sodium starch glycolate and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.|
|Inventor(s):||Roche; Edward J. (Paoli, PA), Reo; Joseph P. (Harleysville, PA)|
|Assignee:||McNeil-PPC, Inc. (Milltown, NJ)|
1. A granulation composition comprising from about 84.0 to about 96.5% medicament, from about 2.0 to about 10% polyvinylpyrrolidone, from about 1.0 to about 4.0% sodium starch
glycolate and from about 0.5 to about 2.0% sodium lauryl sulfate, by weight of the total weight of the granulation composition wherein the granulation composition is coated with hydroxyethylcellulose or a mixture of hydroxyethylcellulose ad
2. The granulation composition of claim 1 wherein the granulation composition is formed by rotogranulation and the individual granulation compositions are substantially spherical in shape.
3. A granulation composition comprising from about 84.0 to about 96.5% ibuprofen, from about 2.0 to about 10.0% polyvinylpyrrolidone, from about 1.0 to about 4.0% sodium starch glycolate, and from about 0.5 to about 2.0% sodium lauryl sulfate, by weight of the total weight of the granulation composition wherein the granulation composition is coated with hydroxyethylcellulose or a mixture of hydroxyethylcellulose and hydroxypropylmethylcellulose.
4. The granulation composition of claim 3 wherein the granulation composition is formed by rotogranulation and the individual granulation compositions are substantially spherical in shape.
For more information try a trial or see the plans and pricing
Serving hundreds of leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.