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Claims for Patent: 5,317,032

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Claims for Patent: 5,317,032

Title: Prostaglandin cathartic
Abstract:The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.
Inventor(s): Ueno; Ryuzo (Nishinomiya, JP), Ueno; Ryuji (Nishinomiya, JP), Kuno; Sachiko (Takarazuka, JP), Oda; Tomio (Itami, JP)
Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (Osaka, JP)
Application Number:07/996,495
Patent Claims: 1. A process for providing a cathartic effect to a patient in need thereof which comprises administering to cathartic-inducing effective amount of a 15-keto-16-halogen PGA, PGE or PGF having the following skeleton: ##STR29## and wherein said skeleton is saturated or contains at least one unsaturated bond which is a 2,3-, 5-6- or 17,18- double bond or a 5,6- triple bond, and is not further substituted or is further substituted at at least one of C-3, C-6, C-17, C-19 and C-20 positions of the skeleton by a halogen atom, an alkyl group, an alkoxy group, a carbonyl group, a hydroxyl group, a phenyl group or a phenoxy group, or a pharmaceutically acceptable 1-ester or salt thereof, and a pharmaceutically acceptable carrier.

2. The process of claim 1, wherein said halogen atom is a fluorine, chlorine or bromine atom.

3. The process of claim 1, wherein said alkyl group is methyl, ethyl, isopropyl or isopropenyl group.

4. The process of claim 1, wherein said alkoxy group is methoxy or ethoxy group.

5. The process of claim 3, wherein said alkyl group is at the C-3, C-17 or C-19 position.

6. The process of claim 1, wherein said carbonyl group is at the C-6 position.

7. The process of claim 1, wherein said alkyl or alkoxy group is at the C-20 position.
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