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Claims for Patent: 5,312,925

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Claims for Patent: 5,312,925

Title: Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dih ydro-2H-indol-2-one-hydrochloride
Abstract:The monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydr o-2H-indole-2-one hydrochloride has advantageous stability for formulation as a neuroleptic agent.
Inventor(s): Allen; Douglas J. M. (New London, CT), Busch; Frank R. (Gales Ferry, CT), DiRoma; Sabeto A. (Uncasville, CT), Godek; Dennis M. (Glastonbury, CT)
Assignee: Pfizer Inc. (New York, NY)
Application Number:07/939,204
Patent Claims: 1. 5-(2-( 4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-in dol-2-one hydrochloride monohydrate.

2. A pharmaceutical composition having neuroleptic activity comprising the compound according to claim 1 in an amount effective in the treatment of neuroleptic diseases, and a pharmaceutically acceptable carrier.

3. A method of treating neuroleptic diseases which comprises administering to a subject in need of treatment a neuroleptic amount of the compound according to claim 1.

4. A process for preparing the compound according to claim 1, which comprises reacting anhydrous 5-(2-(4-1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro -2-H-indol-2-one with aqueous hydrochloric acid, wherein the concentration of the hydrochloric acid in the reaction solution is about 0.7 M.
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