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Claims for Patent: 5,292,740

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Claims for Patent: 5,292,740

Title: Sulfonamides
Abstract:The novel sulfonamides of formula I, ##STR1## in which the symbols R.sup.1 -R.sup.9, R.sup.a, R.sup.b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.
Inventor(s): Burri; Kaspar (Binningen, CH), Clozel; Martine (St. Louis, FR), Fischli; Walter (Allschwil, CH), Hirth; Georges (Huningue, FR), Loffler; Bernd-Michael (Oberrimsingen, DE), Neidhart; Werner (Bartenheim, FR), Ramuz; Henri (Birsfelden, CH)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:07/896,015
Patent Claims: 1. A compound of the formula ##STR12## wherein R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.a ; and

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

R.sup.4 is hydrogen, lower-alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, hydroxy-lower alkoxy, lower-alkoxy-lower alkyl, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, lower-alkylsulphinyl, lower-alkylsulphonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl, or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkyl, lower-alkanoyl, benzoyl, heterocyclylcarbonyl wherein the heterocyclyl is selected from unsubstituted 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl, phenyl-lower alkyl, heterocyclyl methyl wherein the heterocyclyl is selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl, or tetrahydro-pyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkyloxycarbonyloxy; or

R.sup.7 together with R.sup.6 or R.sup.8 signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

Z is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower alkyl;

X and Y each independently are O, S or NH; or YR.sup.5 is lower-alkylsulphinyl;

R.sup.a, R.sup.b, R.sup.c and R.sup.d each independently are hydrogen or lower-alkyl; or R.sup.c and R.sup.d together are methylene, ethylene or isopropylidene; and

n is 1, 2 or 3,

or a stereoisomer or salt thereof.

2. The compound of claim 1, wherein

R.sup.1 is hydrogen lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy or trifluoromethyl; and

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together signify butadienyl, methylenedioxy,

R.sup.4 is hydrogen, lower-alkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxycarboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkanoyl, benzoyl or tetrahydropyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkoxy-carbonyloxy; or

R.sup.7 together with R.sup.6 or R.sup.8 signify butadienyl or --OCH.sub.2 O--;

Z is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or

--SCHR.sup.10 ;

R.sup.10 is hydrogen or lower-alkyl;

X and Y each independently are O, S or NH;

R.sup.a and R.sup.b are hydrogen; and

n is 1, 2 or 3

or a stereoisomer or salt thereof.

3. A compound according to claim 1, wherein Z is --O--.

4. A compound according to claim 2, wherein R.sup.6 is lower-alkoxy and R.sup.7, R.sup.8 and R.sup.9 are hydrogen.

5. A compound according to claim 2, wherein R.sup.6 and R.sup.8 are hydrogen, R.sup.7 is lower-alkoxy and R.sup.9 is halogen.

6. A compound according to claim 1, wherein R.sup.4 is hydrogen, 2-pyrimidinyl, 2- or 3-furyl, 2- or 3-thienyl, morpholino or p-methoxyphenyl.

7. A compound according to claim 1, wherein YR.sup.5 is hydroxy, lower-alkoxysulphinyl or furoyloxy.

8. A compound according to claim 3, selected from the group consisting of

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]benzene sulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-p-isopropylbenze nesulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(o-tolyloxy)-4-pyrimidinyl]benzenesulfon amide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(o-chlorophenyloxy)-4-pyrimidinyl]benzen esulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-chlorophenoxy)-4-pyrimidinyl]-p-isopropylbenzen esulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(m-methoxyphenoxy)-4-pyrimidinyl]benzene sulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-phenoxy-4-pyrimidinyl]benzenesulfonamide

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(p-methoxyphenoxy)-4-pyrimidinyl]benzene sulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(o-ethoxyphenoxy)-4-pyrimidinyl]benzenes ulfonamide,

p-(2,2-dimethylpropyl)-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimi dinyl]benzenesulfonamide,

p-isopropyl-N-[6-(2-hydroxyethoxy)-2-methyl-5-(m-methoxyphenoxy)-4-pyrimidi nyl]benzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-phenyl-4-pyrimidinyl]-p-isopr opylbenzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(2,4,6-trichlorophenoxy)-4-pyrimidinyl]-p-isopropy lbenzenesulfonamide,

N-[6-(2-hydroxyethoxy)-6-(2,4,6-trichlorophenoxy)-4-pyrimidinyl]-o-toluenes ulfonamide,

N-[6-(2-hydroxyethoxy)-5-(2,4,6-trichlorophenoxy)-4-pyrimidinyl]-2,4-xylene sulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-[(2-methoxy-p-tolyl)oxy]-4-pyrimidinyl]b enzenesulfonamide,

N-[5-(2-methoxy-4-methylphenoxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-iso-p ropylbenzenesulfonamide,

N-[5-(2-methoxy-4-methylphenoxy)6-(2-hydroxyethoxy)-4-pyrimidinyl]-o-ethylb enzenesulfonamide,

p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimid inyl]benzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-p-isopr opylbenzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidin yl]-p-isopropylbenzenesulfonamide,

p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(trifluoromethyl )-4-pyrimidinyl]benzenesulfonamide,

N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-tertbut ylbenzenesulfonamide,

N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-isoprop ylbenzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-o-methoxybenzene sulfonamide,

p-tert-butyl-N-[6-(4-hydroxybutoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimid inyl]benzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(2-naphthyloxy)-4-pyrimidinyl]-p-isopropylbenzenes ulfonamide,

N-[6-(2-hydroxyethoxy)-5-(2-naphthyloxy)-4-pyrimidinyl]-p-tert-butylbenzene sulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-propyl-4-pyrimidinyl]-p-isopr opylbenzenesulfonamide,

p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-propyl-4-pyrimid inyl]benzenesulfonamide,

.alpha.,.alpha.,.alpha.-trifluoro-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenox y)-2-methyl-4-pyrimidinyl]-p-toluenesulfonamide,

p-chloro-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl ]benzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-p-(trif luoromethoxy)benzenesulfonamide,

o-ethyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl] benzenesulfonamide,

N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-p-tolue nesulfonamide,

p-tert-butyl-N-[6-(3-hydroxypropoxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimi dinyl]benzenesulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-[(o-methylthio)phenoxy]-4-pyrimidinyl]be nzenesulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-phenyl-4-pyrimidiny l]benzenesulfonamide,

N-[2-amino-6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-p-t-buty lbenzenesulfonamide,

p-t-butyl-N-[6-(2-hydroxyethoxy)-2-methyl-5-[o-(methylthio)phenoxy]-4-pyrim idinyl]benzenesulfonamide and

p-t-butyl-N-[6-(2-hydroxyethoxy)-2-methyl-5-[o-(R,S-methylsulphinyl)phenoxy ]-4-pyrimidinyl]benzenesulfonamide.

9. A compound according to claim 3, selected from the group consisting of:

4-tert-butyl-N-[5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-2-methy l-pyrimidin-4-yl]-benzene-sulfonamide,

4-tert-butyl-N-[5-(2-chloro-5-methoxy-phenoxy)-6-[2-(3-furoyloxy)ethoxy]-2- methyl-pyrimidin-4-yl]-benzene-sulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(thiophen-2-yl )-pyrimidin-4-yl]-benzene-sulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(thiophen-3-yl )-pyrimidin-4-yl]-benzene-sulfonamide,

4-tert-butyl-N-[2-(furan-2-yl)-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-p yrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[2-(furan-3-yl)-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-p yrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyridin-2-yl) -pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyridin-4-yl) -pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyridin-3-yl) -pyrimidin-4-yl]-benzenesulfonamide,

2-[4-(4-tert-butyl-phenylsulphonylamino)-6-(2-hydroxy-ethoxy)-5-(2-methoxy- phenoxy)-pyrimidin-2-yl]-pyridine 1-oxide,

4-[4-(4-tert-butyl-phenylsulphonylamino)-6-(2-hydroxy-ethoxy)-5-(2-methoxy- phenoxy)-pyrimidin-2-yl]-pyridine 1-oxide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-2-[2-(2-hydroxy-ethoxy)ethyl]-5-(2-met hoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-py rimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[2-ethyl-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidi n-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-2-isopropyl-5-(2-methoxy-phenoxy)-pyri midin-4-yl]-benzenesulfonamide,

4-chloro-N-[3-(5-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4 -yl]-benzenesulfonamide,

N-[5-(5-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-4-tr ifluoromethyl-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-2,2'-bipyrimidin -4-yl]-benzenesulfonamide,

4-tert-butyl-N-[5-(4-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-2,2'-bi pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[5-(4-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-2-methy l-pyrimidin-4-yl]-benzene-sulfonamide,

4-tert-butyl-N-[5-(4-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimid in-4-yl]-benzenesulfonamide,

N-[5-(5-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-4-is opropyl-benzenesulfonamide,

N-[5-(5-fluoro-2-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-4-te rt-butyl-benzenesulfonamide,

4-tert-butyl-N-[5-(2-fluoro-6-methoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl] -benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-2-(thiophen-2-yl )-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-2-(2-methoxy-ethyl)-5-(3-methoxy-pheno xy)-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-2-[2-(2-methoxy-ethoxy)ethyl]-5-(3-met hoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide,

3-methylisoxazole-5-carboxylic acid 2-[6-(4-t-butyl-benzenesulfonamino)-5-(3-methoxyphenoxy)pyrimidin-4-yloxy] -ethyl ester,

indole-2-carboxylic acid 2-[6-(4-t-butylbenzenesulfonamino)-5-(3-methoxyphenoxy)pyrimidin-4-yloxy]e thyl ester, and

5-[N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]aminosulfonyl ]-2-methoxyphenoxy acetic acid ethyl ester.

10. The compound, N-[6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-naph thylsulfonamide.

11. (S)-4-tert-B utyl-N-[6-(2,3-dihydroxy-propyloxy)-5-(2-methoxy-phenoxy)-2-(4-methoxypheny l)-pyrimidin-4-yl]-benzenesulfonamide.

12. (RS)-4-tert-Butyl-N-[5-(2-chloro-5 -methoxy-phenoxy)-2-ethyl-6-(2-methylsulphinyl-ethoxy)-pyrimidin-4-yl]-benz enesulfonamide.

13. (RS)-N-[5-( 2-Chloro-5-methoxy-phenoxy)-6-(2-methylsulphinyl-ethoxy)-pyrimidin-4-yl]-1, 3-benzodioxol-5-sulfonamide.

14. 4-tert-Butyl-N-[6-(2-hyd roxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-benze nesulfonamide.

15. A compound according to claim 2, wherein Z is or vinylene.

16. A compound according to claim 15, selected from the group consisting of

2-[[5-[(E/Z)-styryl]-6-p-toluenesulphonamido-4-pyrimidinyl]oxy]ethyl acetate and

N-[6-(2-hydroxyethoxy)-5-([E/Z)-styryl]-4-pyrimidinyl]-p-toluenesulfonamide

17. A compound of the formula ##STR13## wherein R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.a ; and

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

R.sup.4 is hydrogen, lower-alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, hydroxy-lower alkoxy, lower-alkoxy-lower alkyl, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, lower-alkylsulphinyl, lower-alkylsulphonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxycarboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkyl, lower alkanoyl, benzoyl, heterocyclylcarbonyl wherein the heterocyclyl is selected from unsubstituted 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl, phenyl-lower alkyl, heterocyclyl methyl wherein the heterocyclyl is selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl, or tetrahydropyran-2-yl;

Z is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower-alkyl;

R.sup.a and R.sup.b each independently are hydrogen or lower-alkyl; and

n is 1, 2 or 3.

18. A pharmaceutical composition comprising a compound of the formula ##STR14## wherein R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.a ; and

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together are butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

R.sup.4 is hydrogen, lower-alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, hydroxy-lower alkoxy, lower-alkoxy-lower alkyl, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, lower-alkylsulphinyl, lower-alkylsulphonyl, 2-methoxy-3-hydroxyproxy, 2-hydroxy-3-phenylpropyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxycarboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkyl, lower alkanoyl, benzoyl, heterocyclylcarbonyl wherein the heterocyclyl is selected from unsubstituted 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl, phenyl-lower alkyl, heterocyclyl methyl wherein the heterocyclyl is selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl, or tetrahydropyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkyloxy-carboyloxy; or

R.sup.7 together with R.sup.6 or R.sup.8 signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower alkyl;

X and Y each independently are O, S or NH; or YR.sup.5 is lower-alkylsulphinyl;

R.sup.a, R.sup.b, R.sup.c and R.sup.d each independently are hydrogen or lower-alkyl; or R.sup.c and R.sup.d together signify methylene, ethylene or isopropylidene; and

n is 1, 2 or 3

or a stereoisomer or salt thereof and an inert carrier.

19. The pharmaceutical composition of claim 18, wherein

R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl;

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together are butadienyl, methylenedioxy;

R.sup.4 is hydrogen, lower-alkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkanoyl, benzoyl or tetrahydropyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkoxy-carboyloxy; or

together with R.sup.6 or R.sup.8 signify butadienyl or --OCH.sub.2 O--;

Z is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower-alkyl;

X and Y each independently are O, S or NH;

R.sup.a and R.sup.b are hydrogen; and

n is 1, 2 or 3

or a stereoisomer or salt thereof.

20. A method of treating disorders associated with endothelin activities comprising administering to a host in need of such treatment an effective amount of a compound of the formula ##STR15## wherein R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.a ;

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

R.sup.4 is hydrogen, lower-alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, hydroxy-lower alkoxy, lower-alkoxy-lower alkyl, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, lower-alkylsulphinyl, lower-alkylsulphonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower-alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkyl, lower-alkanoyl, benzoyl, heterocyclylcarbonyl wherein the heterocyclyl is selected from unsubstituted 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl, phenyl-lower alkyl, heterocyclyl methyl wherein the heterocyclyl is selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl, or tetrahydro-pyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkyloxycarbonyloxy; or

R.sup.7 together with R.sup.6 or R.sup.8 signify butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;

is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower-alkyl;

X and Y each independently are O, S or NH; or YR.sup.5 is lower-alkylsulphinyl;

R.sup.a, R.sup.b, R.sup.c and R.sup.d each independently are hydrogen or lower-alkyl; or R.sup.c and R.sup.d together signify methylene, ethylene or isopropylidene; and

n is 1, 2 or 3

or a stereoisomer or salt thereof.

21. The method of claim 20, wherein

R.sup.1 is hydrogen, lower-alkyl, lower alkoxy, lower-alkylthio, halogen or trifluoromethyl;

R.sup.2 is hydrogen, halogen, lower-alkoxy, trifluoromethyl;

R.sup.3 is hydrogen, halogen, lower-alkyl, lower-alkylthio, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, lower-alkoxy or trifluoromethoxy; or

R.sup.2 and R.sup.3 together are butadienyl or methylenedioxy;

R.sup.4 is hydrogen, lower-alkyl, trifluoromethyl, lower-alkoxy, lower alkylthio, lower-alkylthio-lower-alkyl, hydroxy-lower-alkyl, amino-lower alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, unsubstituted phenyl amino, phenylamino substituted with halogen, lower-alkyl, lower alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl, phenyl substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenylthio, phenylthio substituted with halogen, lower-alkyl, lower alkoxy carboxyl or trifluoromethyl, unsubstituted phenoxy, phenoxy substituted with halogen, lower alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted phenyl-lower alkyl, phenyl-lower-alkyl substituted with halogen, lower-alkyl, lower-alkoxy-carboxyl or trifluoromethyl, unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, pyrimidyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, imidazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl, isoquinolyl and quinazolyl or heterocyclyl as defined above substituted by lower alkyl, lower alkoxy, halogen, phenyl or phenyl-lower alkyl;

R.sup.5 is hydrogen, lower-alkanoyl, benzoyl or tetrahydropyran-2-yl;

R.sup.6 to R.sup.9 are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, hydroxy, hydroxymethyl, cyano, carboxyl, formyl, methylsulphinyl, methylsulphonyl, methylsulphonyloxy or lower-alkoxycarbonyloxy; or

R.sup.7 together with R.sup.6 or R.sup.8 signify butadienyl or --OCH.sub.2 O--;

Z is --O--, --S--, vinylene, --CO--, OCHR.sup.10 -- or --SCHR.sup.10 ;

R.sup.10 is hydrogen or lower-alkyl;

X and Y each independently are O, S or NH;

R.sup.a and R.sup.b are hydrogen; and

n is 1, 2 or 3

or a stereoisomer or salt thereof.

22. The pharmaceutical composition of claim 18, wherein Z is --O--.

23. The pharmaceutical composition of claim 19, R.sup.6 is lower-alkoxy and R.sup.7, R.sup.8 and R.sup.9 are hydrogen.

24. The pharmaceutical composition of claim 19, wherein R.sup.6 and R.sup.8 are hydrogen, R.sup.7 is lower-alkoxy and R.sup.9 is halogen.

25. The pharmaceutical composition of claim 18, wherein R.sup.4 is hydrogen, 2-pyrimidinyl, 2- or 3-furyl, 2- or 3-thienyl, morpholino or p-methoxyphenyl.

26. The method of claim 20, wherein the disorder is a circulatory disorder.

27. The method of claim 26, wherein the circulatory disorder is hypertension, ischemia, vasopasms or angina pectoris.

28. The method of claim 20, wherein Z is --O--.

29. The method of claim 21, wherein R.sup.6 is lower-alkoxy and R.sup.7, R.sup.8 and R.sup.9 are hydrogen.

30. The method of claim 21, wherein R.sup.6 and R.sup.8 are hydrogen, R.sup.7 is lower-alkoxy and R.sup.9 is halogen.

31. The method of claim 20, wherein R.sup.4 is hydrogen, 2-pyrimidinyl, 2- or 3-furyl, 2- or 3-thienyl, morpholino or p-methoxyphenyl.

32. A compound of the formula ##STR16## wherein R.sup.1 is hydrogen;

R.sup.2 is hydrogen;

R.sup.3 is lower alkyl;

R.sup.4 is hydrogen, lower-alkyl, 2-thienyl, 3-thienyl or 3-furyl;

R.sup.6 is lower-alkoxy;

R.sup.7 to R.sup.9 are hydrogen;

R.sup.11 is halogen

Z is --O--

W is 1,3-dioxolan-4-ylmethoxy, 2,2-dimethyl-1,3-dioxolan-4-ylmethoxy or 2,3-dihydroxy-propoxy

or a stereiosomer or salt thereof.

33. A compound according to claim 32 selected from the group consisting of:

(S)-4-tert-butyl-N-[6-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-5-(2-methoxy- phenoxy)-2-methyl-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[6-(2,3-dihydroxy-propoxy-5-(2-methoxy-phenoxy)-2-methyl -6-(2-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[5-(5-fluoro-2-methoxy-phenoxy)-6-(2,2-dimethyl-1,3-diox olan-4-ylmethoxy)-pyrimidin-4-yl]-benzenesulfonamide,

(S)-4-tert-butyl-N-[5-(5-fluoro-2-methoxy-phenoxy)-6-(2,2-dimethyl-1,3-diox olan-4-ylmethoxy)-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-(5-fluoro-2-methoxy-phenoxy)-6-(2,3-dihydroxy-propoxy-py rimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-[(S)-1,3-dioxolan-4-ylmethoxy]-5-(2-methoxy-phenoxy)-2-(t hiophen-2-yl)-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[6-(2,3-dihydroxy-propoxy)-5-(2-methoxy-phenoxy)-2-(thio phen-2-yl)-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-(R)-1,3-dioxolan-4-lymethoxy]-5-(2-methoxy-phenoxy)-2-(th iophen-2-yl)-pyrimidin-4-yl]-benzenesulfonamide,

(S)-4-tert-butyl-N-[6-(2,3-dihydroxy-propoxy)-5-(2-methoxy-phenoxy)-2-(thio phen-2-yl)-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[6-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-5-(2-methoxy- phenoxy)-2-(thiophen-3-yl)-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-[(S)-2,3-dihydroxy-propoxy]-5-(2-methoxy-phenoxy)-2-(thio phen-3-yl)-pyrimidin-4-yl]-benzenesulfonamide,

(S)-4-tert-butyl-N-[(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-5-(2-methoxy-ph enoxy)-2-(thiophen-3-yl)-pyrimidin-4-yl]-benzenesulfonamide,

4-tert-butyl-N-[6-[(R)-2,3-dihydroxy-propoxy]-5-(2-methoxy-phenoxy)-2-(thio phen-3-yl)-pyrimidin-4-yl]-benzenesulfonamide,

(S)-4-tert-butyl-N-[6-(2,2-dimethyl-1,3-dioxolan-4-yl-methoxy)-2-(furan-3-y l)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[2-(furan-3-yl)-6-(2,3-dihydroxy-propoxy)-5-(2-methoxy-p henoxy)-pyrimidin-4-yl]-benzenesulfonamide,

(R)-4-tert-butyl-N-[6-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-2-(furan-3-yl )-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide; and

(S)-4-tert-butyl-N-[2-(furan-3-yl)-6-(2,3-dihydroxy-propoxy)-5-(2-methoxy-p henoxy)-pyrimidin-4-yl]-benzenesulfonamide.
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