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Claims for Patent: 5,288,703

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Claims for Patent: 5,288,703

Title: Method for enhancing gut absorption
Abstract:The present invention provides a method for enhancing the gut absorption in a mammal. Specifically, gut absorption in a mammal can be enhanced by the administration of glutamine, or glutamine equivalent, in combination with one or more agents, said agents selected from the group consisting of growth hormone (GH), an agent capable of enhancing endogenous GH production, insulin like growth factor 1 (IGF-1), or an agent capable of enhancing endogenous IGF-1 production.
Inventor(s): Wilmore; Douglas (Brookline, MA)
Assignee: Brigham and Women's Hospital (Boston, MA)
Application Number:07/957,174
Patent Claims: 1. A method of increasing gut absorption of nutrients in a mammal, comprising co-administering to said mammal a therapeutically effective amount of glutamine and a therapeutically effective amount of growth hormone.

2. A method of increasing gut absorption of nutrients in a mammal, comprising co-administering to said mammal a therapeutically effective amount of glutamine and a therapeutically effective amount of growth hormone, wherein said mammal has undergone bowel resection greater than eleven months prior to said co-administration.

3. The method of claims 1 or 2, wherein said mammal is a human.

4. The method of claims 1 or 2, wherein said composition is administered parenterally.

5. The method of claims 1 or 2, wherein said composition is administered enterally.

6. The method of claims 1 or 2, wherein said therapeutically effective amount of an agent contains a dosage of said growth hormone in the range of 0.05 to 0.3 mg/kg/day.

7. The method of claims 1 or 2, wherein said therapeutically effective amount of glutamine contains a dosage of said glutamine in the range of 0.2 to 3 gm/kg/day.

8. The method of claims 1 or 2, wherein said treatment is a result of malabsorption syndrome.

9. The method of claim 8, wherein said malabsorption syndrome is a result of short gut syndrome.

10. The method of claim 9, wherein said malabsorption syndrome is a result of surgical excision of all or a portion of the small intestine.

11. The method of claim 10, wherein said surgical excision is a result of a condition selected from the group consisting of; traumatic disease, congenital atresia, abdominal radiation injury, chronic adhesive obstruction, and mesenteric tumors.

12. The method of claim 8, wherein said malabsorption syndrome is a result a pathological condition selected from the group consisting of; meconium ileus, volvulus, gastroschisis, necrotizing enterocolitis, Hirschprung's disease, inflammatory bowel disease, vascular damage, mesenteric tumors, infectious diarrhea, secretory diarrhea and AIDs-related diarrhea.

13. The method of claim 12, wherein said vascular damage is selected from the group consisting of; thrombosis of the superior mesenteric artery, thrombosis of the superior mesenteric vein, thrombosis of the portal vein.
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