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Claims for Patent: 5,286,754

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Claims for Patent: 5,286,754

Title: Pharmaceutical formulations of ciprofloxacin
Abstract:A pharmaceutical formulation comprising by weight 30 to 95% of 1cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carb oxylic acid; 4.5 to 25% of a dry binder based on cellulose; 0 to 30% of a disintegration auxiliary based on starch; 0.5 to 10% of a disintegration auxiliary based on a cellulose derivative and/or a cross-linked polyvinyl-pyrrolidone; 0 to 2% of a flow-improving agent, and 0 to 3% of a lubricant. Tablets and capsules made from granules of the formulation, about 0.8 to 2 mm in size, exhibit high bioavailability and excellent storage stability.
Inventor(s): Streuff; Bernd (Wermelskirchen, DE), Luchtenberg; Helmut (Niederkassel, DE)
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Application Number:07/246,576
Patent Claims: 1. A pharmaceutical formulation of high biological availability and storage life consisting of by weight 583 parts of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-car boxylic acid HCl monohydrate; 55 parts of microcrystalline cellulose; 72 parts of moist starch; 30 parts of cross-linked polyvinyl-pyrrolidone; 5 parts of silicon dioxide; and 5 parts of magnesium stearate.
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