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Claims for Patent: 5,260,301

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Claims for Patent: 5,260,301

Title: Pharmaceutical solution containing FK-506
Abstract:A pharmaceutical solution which contains the compound of the general formula having the immusuppreseive activity is disclosed. ##STR1##
Inventor(s): Nakanishi; Shigeo (Neyagawa, JP), Yamanaka; Iwao (Osaka, JP)
Assignee: Fujisawa Pharmaceutical Co., Ltd. (Osaka, JP)
Application Number:07/984,239
Patent Claims: 1. A pharmaceutical solution which comprises FK 506, a pharmaceutically acceptable surface active agent comprising polyoxyethylene hydrogenated castor oil, and a pharmaceutically acceptable nonaqueous solvent selected from the group consisting of ethanol, pyropylene glycol, glycerin and polyethylene glycol.

2. The pharmaceutical solution of claim 1, wherein the FK 506 and the pharmaceutically acceptable surface active agent are in the ratio of 1:1 to 1:100 by weight.

3. The pharmaceutical solution of claim 1, wherein the pharmaceutically acceptable nonaqueous solvent is propylene glycol.

4. The pharmaceutical solution of claim 1, wherein the pharmaceutically acceptable nonaqueous solvent is glycerin.

5. The pharmaceutical solution of claim 1, wherein the pharmaceutically acceptable nonaqueous solvent is polyethylene glycol.

6. The pharmaceutical formulation of claim 1, wherein the polyoxyethylene hydrogenated castor oil is polyoxyethylene hydrogenated Castor Oil 60.

7. The pharmaceutical solution of claim 1 wherein the pharmaceutically acceptable nonaqueous solvent is ethanol.

8. A process for preparing a pharmaceutical solution, which comprises mixing FX 506 and a pharmaceutically acceptable surface active agent comprising polyoxyethylene hydrogenated caster oil in a pharmaceutically acceptable nonaqueous solvent selected from the group consisting of ethanol, propylene glycol, glycerin and polyethylene glycol.
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