Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Chubb
Federal Trade Commission
Merck
Citi
AstraZeneca
Covington
UBS
Daiichi Sankyo

Generated: June 20, 2018

DrugPatentWatch Database Preview

Claims for Patent: 5,256,664

« Back to Dashboard

Summary for Patent: 5,256,664
Title: Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
Abstract:2-(3-[4-(3-Halophenyl)-1-piperazinyl]propyl derivatives of certain 4-alkyl- or 4-phenoxyalkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and triazol-3,5-diones are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.
Inventor(s): Mayol; Robert F. (Durham, CT), Luke; George M. (LaFayette, NY)
Assignee: Bristol-Myers Squibb Company (New York, NY)
Application Number:07/875,044
Patent Claims: 1. A compound of Formula I ##STR10## or a pharmaceutically acceptable acid addition salt and/or hydrate thereof wherein

R is halogen or trifluoromethyl;

X is oxygen or acetyl;

the single and dotted lines represent either a covalent single or double bond;

n is an integer from 2 to 4; and

Z is hydrogen or ##STR11## in which R.sup.1 is hydrogen, halogen, C.sub.1-4 alkoxy or trifluoromethyl.

2. The compound of claim 1 wherein X is acetyl.

3. The compound of claim 1 wherein X is oxygen.

4. The compound of claim 1 wherein Z is ##STR12##

5. The compound of claim 1 wherein R is 3-chloro.

6. The compound of claim 4 wherein R.sup.1 is hydrogen.

7. The compound of claim 2, 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)-5-acetyl-2,4-dihydro-4-(2-p henoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride.

8. The compound of claim 3, 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)-4-(2-phenoxyethyl)-4H-1,2,4 -triazole-3,5(1H,2H)-dione hydrochloride.

9. The antidepressant method which comprises administering to a mammalian host with depression, an effective antidepressant dose of a compound claimed in claim 1.

10. The antidepressant method which comprises administering to a mammalian host with depression, an effective antidepressant dose of a compound claimed in claim 7.

11. The antidepressant method which comprises administering to a mammalian host with depression, an effective antidepressant dose of a compound claimed in claim 8.

12. A pharmacological composition in unit dosage form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and an effective antidepressant amount of a compound claimed in claim 1.

13. A pharmacological composition in unit dosage form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and an effective antidepressant amount of a compound claimed in claim 7.

14. A pharmacological composition in unit dosage form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and an effective antidepressant amount of a compound claimed in claim 8.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Mallinckrodt
QuintilesIMS
Daiichi Sankyo
Federal Trade Commission
Boehringer Ingelheim
AstraZeneca
Covington
Chubb

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.