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Last Updated: April 23, 2024

Claims for Patent: 5,254,539

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Summary for Patent: 5,254,539

Title:	Method of treating HIV with 2',3'-dideoxyinosine
Abstract:	A method for tearing retroviral infections including acquired immune deficiency syndrome (AIDS) with 2',3'-dideoxyinosine or 2',3'-dideoxyadenosine is disclosed. This antiviral effect is irreversible with 2',3'-dideoxyinosine and 2',3'-dideoxyadenosine but reversible with 2',3'-dideoxyguanosine.
Inventor(s):	Mitsuya; Hiroaki (Rockville, MD), Broder; Samuel (Bethesda, MD)
Assignee:	U.S. Government, Dept. of Health and Human Services, c/o National (Bethesda, MD)
Application Number:	07/663,288
Patent Claims:	1. A method for treating an individual infected with human immunodeficiency virus, comprising administering a therapeutically effective amount of 2',3'-dideoxyinosine or a pharmaceutically acceptable salt thereof, to said individual. 2. The method according to claim 1 wherein the therapeutically effective amount of 2',3'-dideoxyinosine is administered orally. 3. The method according to claim 1 wherein the therapeutically effective amount of 2',3'-dideoxyinosine is administered intravenously. 4. The method according to claim 1 wherein the therapeutically effective amount of 2',3'-dideoxyinosine is administered intramuscularly. 5. The method according to claim 1 wherein the therapeutically effective amount of 2',3'-dideoxyinosine is administered subcutaneously. 6. The method according to claim 1 wherein the 2',3'-dideoxyinosine is administered to the individual to achieve peak plasma concentrations ranging from about 0.5 uM to about 50 uM. 7. The method according to claim 1 in which the 2',3'-dideoxyinosine is administered to the individual to achieve peak plasma concentrations ranging from about 1 uM to about 30 uM.

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