Claims for Patent: 5,252,341

Summary for Patent: 5,252,341

Title:	Tablets and granulates containing mesna as active substance
Abstract:	A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.
Inventor(s):	Dieter Sauerbier, Jurgen Engel, Eckhard Milsmann
Assignee:	Evonik Operations GmbH
Application Number:	US07/930,783
Patent Claims:	1. A granulate containing, as active ingredient mesna, in combination with, for each part by weight of mesna: 0.1-1 parts by weight of a binding agent. 2. A granulate as set forth in claim 1 containing a member of the group consisting of: 0.01-0.2 parts by weight of a lubricant and 0.1-1 parts by weight of a filling agent. 3. A granulate as set forth in claim 1 or claim 2 containing at least one member of the group consisting of flavoring, sweetening and aromatizing substance. 4. A granulate according to claim 1 or claim 2 which is coated with a conventional pharmaceutically-acceptable film. 5. A process for the manufacture of a granulate containing, as active substance mesna, in combination with, for each part by weight of mesna: 0.01-1 parts by weight of a binding agent said process including the step of granulating mesna and at least a portion of said binding agent with at least one member of the group consisting of C1 -C4 -alcohols and acetone or a mixture of at least one of said organic agents with water. 6. A process as set forth in claim 5 in which there is present, during the granulation,0.1-1 parts by weight of a filling agent and/or 0.1-0.2 parts by weight of a lubricant. 7. A process as set forth in claim 5 or claim 6 including the step of drying the granulate. 8. A process as set forth in claim 7 including applying a pharmaceutically-acceptable coating to the dried granulate. 9. As set forth in claim 5 or claim 6 including the step of drying the granulate, adding a member of the group consisting of flavoring, sweetening and aromatizing agents and homogenizing the entire mixture. 10. A process as set forth in claim 9 including applying a pharmaceutically acceptable coating to the homogenized pro duct.