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Serving 500+ biopharmaceutical companies globally:

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Generated: August 18, 2017

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Title: Tablets and granulates containing mesna as active substance
Abstract:A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain 0.01-1 parts by weight of a binding agent 0.03-0.4 parts by weight of a disintegrant 0.01-0.2 parts by weight of a lubricant and 0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.
Inventor(s): Sauerbier; Dieter (Werter, DE), Engel; Jurgen (Alzenau, DE), Milsmann; Eckhard (Bielefeld, DE)
Assignee: Degussa Aktiengesellschaft (DE)
Application Number:07/930,783
Patent Claims: 1. A granulate containing, as active ingredient mesna, in combination with, for each part by weight of mesna: 0.1-1 parts by weight of a binding agent.

2. A granulate as set forth in claim 1 containing a member of the group consisting of: 0.01-0.2 parts by weight of a lubricant and 0.1-1 parts by weight of a filling agent.

3. A granulate as set forth in claim 1 or claim 2 containing at least one member of the group consisting of flavoring, sweetening and aromatizing substance.

4. A granulate according to claim 1 or claim 2 which is coated with a conventional pharmaceutically-acceptable film.

5. A process for the manufacture of a granulate containing, as active substance mesna, in combination with, for each part by weight of mesna: 0.01-1 parts by weight of a binding agent said process including the step of granulating mesna and at least a portion of said binding agent with at least one member of the group consisting of C.sub.1 -C.sub.4 -alcohols and acetone or a mixture of at least one of said organic agents with water.

6. A process as set forth in claim 5 in which there is present, during the granulation,

0.1-1 parts by weight of a filling agent and/or

0.1-0.2 parts by weight of a lubricant.

7. A process as set forth in claim 5 or claim 6 including the step of drying the granulate.

8. A process as set forth in claim 7 including applying a pharmaceutically-acceptable coating to the dried granulate.

9. As set forth in claim 5 or claim 6 including the step of drying the granulate, adding a member of the group consisting of flavoring, sweetening and aromatizing agents and homogenizing the entire mixture.

10. A process as set forth in claim 9 including applying a pharmaceutically acceptable coating to the homogenized pro duct.
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Federal Trade Commission
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