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Last Updated: March 29, 2024

Claims for Patent: 5,240,711


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Summary for Patent: 5,240,711
Title: Transdermal therapeutic system comprising as active component buprenorphine
Abstract:The controlled release of buprenorphine or the pharmaceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer. Said reservoir layer of said system comprises 20 to 90%-wt polymeric material, 0.1 to 30%-wt softener, 0.1 to 20%-wt buprenorphine base or one of the pharmaceutically acceptable salts thereof, and 0.1 to 30%-wt solvent for the active substance base.
Inventor(s): Hille; Thomas (Neuwied, DE), Deurer; Lothar (Koblenz, DE), Hoffmann; Hans-Rainer (Neuwied, DE)
Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KG (Neuwied, DE)
Application Number:07/951,030
Patent Claims: 1. A transdermal therapuetic system for the administration of buprenorphine to the skin comprising a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer, the reservoir layer by weight comprising 20 to 90% of a polymeric matrix, 0.1 to 30% of a softening agent, 0.1 to 20% of buprenorphine base or of a pharmaceutically acceptable salt thereof and 0.1 to 30% of a solvent for the buprenorphine or salt thereof.

2. The transdermal therapeutic system according to claim 1, wherein the backing layer is composed of a flexible material.

3. The transdermal therapeutic system according to claim 1, wherein the backing layer is composed of a inflexible material.

4. The transdermal therapeutic system according to claim 1, wherein the backing layer is an aluminum foil.

5. The transdermal therapeutic system according to claim 1, wherein the polymeric matrix is at least one of rubber, a rubber-like synthetic homo-, co- or blockpolymer, a urethane and silicone.

6. The transdermal therapeutic system according to claim 1, wherein the softening agent is at least one of dodecanol, undecanol, octanol, a glycol and glycanol.

7. The transdermal therapeutic system according to claim 1, wherein the solvent is a monoester of a dicarboxylic acid.

8. The transdermal therapeutic system according to claim 1, wherein the solvent is at least one of monomethyl glutarate and monomethyl adipate.

9. The transdermal therapeutic system according to claim 4, wherein the polymer is a copolymer of 2-ethylhexyl acrylate, vinyl acetate and acrylic acid, the softening agent is dodecanol and the solvent is monomethyl glutarate.

10. The transdermal therapeutic system according to claim 1, wherein by weight the polymer is present in about 55%, the buprenorphine in about 10%, the solvent in about 10% and the softener in about 15%.

11. A transdermal therapeutic system according to claim 1, wherein the solvent is present in from about 25 to 100% the weight of the buprenorphine.

12. The transdermal therapeutic system according to claim 1, which also comprises a removable protective layer.

13. The transdermal therapeutic system according to claim 1, wherein the pressure-sensitive adhesive reservoir layer comprises a polymer based on an acrylate, a methacrylate or a combination thereof.

14. The transdermal therapeutic system according to claim 1, wherein the softening ester is a medium-chain triglyceride of the caprylic/capric acids of coconut oil .

15. The transdermal therapeutic system according to claim 1, wherein the solvent has at least one acidic group.

16. A laminated composite for administering buprenorphine or a pharmaceutically acceptable salt thereof to an individual transdermally comprising

(a) a polymer backing layer that is substantially impermeable to buprenorphine or the pharmaceutically acceptable salt thereof; and

(b) a reservoir layer comprising an acrylate pressure-sensitive adhesive, 0.1 to 20% of buprenorphine base or of a pharmaceutically acceptable salt thereof, 0.1 to 30% of an ester of a carboxylic acid acting as a softening agent and 0.1 to 30% of a solvent for buprenorphine having at least one acidic group.

17. A liminated composite for administering buprenorphine or a pharmaceutically acceptable salt thereof to an individual transdermally comprising

(a) a polymer backing layer that is substantially impermeable to buprenorphine or the pharmaceutically acceptable salt thereof; and

(b) a reservoir layer comprising an acrylate pressure-sensitive adhesive, 0.1 to 20% of buprenorphine base or of a pharmaceutically acceptable salt thereof, 0.1 to 30% of an ester of a carboxylic acid acting as a softening agent and 0.1 to 30% of a solvent for buprenorphine having at least one acidic group, wherein the skin contact area of the composite is 16 cm.sup.2 and the rate of administration from the composite is about 40 .mu.g/hr.

18. The transdermal therapeutic system according to claim 1, wherein the softening agent is an ester of a carboxylic acid.

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