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Claims for Patent: 5,229,382

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Claims for Patent: 5,229,382

Title: 2-methyl-thieno-benzodiazepine
Abstract:2-Methyl-10-(4-methyl-1-piperazinyl)-4H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##
Inventor(s): Chakrabarti; Jiban K. (Frimley, GB2), Hotten; Terrence M. (Farnborough, GB2), Tupper; David E. (Reading, GB2)
Assignee: Lilly Industries Limited (Basingstoke, GB2)
Application Number:07/890,348
Patent Claims: 1. 2-Meth yl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable acid addition salt thereof together with a pharmaceutically acceptable diluent or carrier therefor.

3. A pharmaceutical composition in capsule or tablet form comprising from 2.5 to 5 mg of the compound of claim 1 together with a pharmaceutically acceptable diluent or carrier therefor.

4. A method of treating an animal, including a human, suffering from or susceptible to psychosis, acute mania or mild anxiety states, which comprises administering an effective amount of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof.

5. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to psychosis.

6. A method of claim 5 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof.

7. A method of claim 5 for treating an animal, including a human, suffering from or susceptible to schizophrenia.

8. A method of claim 7 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition solution salt thereof.

9. A method of claim 5 for treating an animal, including a human, suffering from or susceptible to schizophreniform diseases.

10. A method of claim 9 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof.

11. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to acute mania.

12. A method of claim 11 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof.

13. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to mild anxiety states.

14. A method of claim 13 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof.

15. A pharmaceutical composition in capsule or tablet form comprising from 0.1 to 20 mg of the compound of claim 1 together with a pharmaceutically acceptable diluent or carrier therefor.
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