DrugPatentWatch Database Preview
« Back to Dashboard
Summary for Patent: 5,214,036
|Title:||Benzoporphyrin derivatives for photodynamic therapy|
|Abstract:||Green porphyrins (Gp), compounds important in photodynamic therapy, have been associated with lipocomplexes to reduce the required amount of photosensitizer through higher effective absorption and increased specificity. BPDs, especially in conjunction with the HDL fraction of plasma lipoproteins, has been shown to be particularly effective in this context. Pharmaceutical compositions in which these combinations are the active ingredients for use in diagnosis and treatment of tumors are also disclosed.|
|Inventor(s):||Allison; Beth A. (Vancouver, CA), Richter; Anna M. (Vancouver, CA), Pritchard; P. Haydn (Vancouver, CA), Levy; Julia G. (Vancouver, CA)|
|Assignee:||University of British Columbia (British Columbia, CA)|
1. A pharmaceutical composition for photodynamic therapy comprising:
a green porphyrin compound having a formula selected from the group consisting of ##STR4## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen, carbalkoxy (2-6 C), alkyl (1-6 C) sulfonyl, aryl (6-10 C) sulfonyl, aryl (6-10 C), and cyano, further wherein at least one of R.sup.1 and R.sup.2 is not hydrogen;
each R.sup.3 is independently selected from the group consisting of alkyl (1-6 C), carboxyalkyl (2-6 C) and salts and esters thereof; and
R.sup.4 is selected from the group consisting of --CH.dbd.CH.sub.2, --CH.sub.2 OR', --CHO, --COOR', --CH(OR')CH.sub.3, --CH(OR')CH.sub.2 OR', --CH(SR')CH.sub.3, --CH(NR'.sub.2)CH.sub.3, --CH(CN)CH.sub.3, --CH(COOR')CH.sub.3, --CH(OOCR')CH.sub.3, --CH(halo)CH.sub.3, and --CH(halo)CH.sub.2 (halo), wherein each R' is hydrogen or alkyl (1-6 C);
a lipocomplex; and
a pharmaceutically acceptable injectable carrier solution.
2. A composition of claim 1 wherein the green porphyrin is BPD-DA.
3. A composition of claim 1 wherein the green porphyrin is BPD-MA.
4. A composition of claim 1 wherein the lipocomplex is a lipoprotein mixture including HDL's, LDL's, VLDL's or combinations thereof.
5. The composition of claim 4 wherein the lipoprotein mixture consists essentially of HDL's.
6. The composition of claim 4 wherein the lipoprotein mixture consists essentially of LDL's.
For more information try a trial or see the plans and pricing
Serving leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.