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Claims for Patent: 5,212,326

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Claims for Patent: 5,212,326

Title: Sodium hydrogen divalproate oligomer
Abstract:This invention concerns certain diethyl- or dipropylacetic acid salts of sodium valproate which have physiological properties similar to those of valproic acid or sodium valproate but show highly superior stability characteristics.
Inventor(s): Meade; Edwin M. (Duncan, CA)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:07/637,828
Patent Claims: 1. An oligomer having a 1:1 molar ratio of sodium valproate and valproic acid of the unit formula, (CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 Na/(CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 H, and containing about 4 to 6 such units.

2. An oral pharmaceutical dosage form for treating the symptoms of epileptic seizures or convulsions, containing as the active principal an oligomer having a 1:1 molar ratio of sodium valproate and valproic acid of the unit formula, (CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 Na/(CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 H, and containing about 4 to 6 such units.

3. An oligomer having a 1:1 molar ratio of sodium valproate and valproic acid of the unit formula, (CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 Na/(CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 H, and containing about 6 such units.

4. An oral pharmaceutical dosage form for treating the symptoms of epileptic seizures or convulsions, containing as the active principal an oligomer having a 1:1 molar ratio of sodium valproate and valproic acid of the unit formula, (CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 Na/(CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 H, and containing about 6 such units.

5. An oligomer having a 1:1 molar ratio of sodium valproate and valproic acid of the unit formula, (CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 Na/(CH.sub.3 CH.sub.2 CH.sub.2).sub.2 CHCO.sub.2 H, and having physical/chemical properties as follows:

a. stable, white crystalline powder;

b. melting point of 98.degree.-100.degree. C.; and

c. an infrared spectrum having strong absorption bands at about 2957, 2872, 2932, 1685, 1555 and 1370 cm.sup.-1.
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