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Claims for Patent: 5,212,176

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Claims for Patent: 5,212,176

Title: R(+)-terazosin
Abstract:R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.
Inventor(s): Kyncl; John J. (Lake Forest, IL), Horrom; Bruce W. (Waukegan, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:07/546,349
Patent Claims: 1. The compound having the name R(+)-2-(4-((tetrahydro-2-furanyl)carbonyl)piperazinyl)-6,7-dimethoxy-4-qui nazolinamine hydrochloride dihydrate having an optical rotation [.alpha.].sub.D.sup.28.5.degree. C. (C=1, water) of 23.9.degree. or greater.

2. A pharmaceutical composition comprising a therapeutically effective amount of the compound as defined by claim 1 in combination with a pharmaceutically acceptable carrier.

3. A method of treating hypertension in a mammal in need of such treatment comprising administering a therapeutically effective amount of of the compound as defined by claim 1.

4. A method of treating benign prostatic hyperplasia in a mammal in need of such treatment comprising administering a therapeutically effective amount of the compound as defined by claim 1.

5. A method of treating hyperinsulinemia in a mammal in need of such treatment comprising administering a therapeutically effective amount of the compound as defined by claim 1.

6. A method of treating congestive heart failure in a mammal in need of such treatment comprising administering a therapeutically effective amount of the compound as defined by claim 1.
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