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Claims for Patent: 5,210,081

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Claims for Patent: 5,210,081

Title: Alkali metal 8,9-dehydroestrone sulfate esters
Abstract:This invention presents alkali metal salts of 8,9-dehydroestrone, its sulfate ester, and stable compositions thereof, as well as processes for their production. The sulfate ester salts are useful in estrogen replacement therapy.
Inventor(s): Raveendranath; Panolil C. (Plattsburgh, NY), Wichtowski; John A. (Albans, VT)
Assignee: American Home Products Corporation (New York, NY)
Application Number:07/841,694
Patent Claims: 1. A composition of matter consisting essentially of an alkali metal salt of 8,9-dehydroestrone-3-sulfate ester.

2. A composition of matter of claim 1 in which said alkali metal is sodium.

3. A composition of matter of claim 1 in which said alkali metal is potassium.

4. A composition of matter of claim 1 in which said alkali metal is lithium.

5. A composition of matter comprising an alkali metal salt of 8,9-dehydroestrone-3-sulfate in combination with tris(hydroxymethyl)aminomethane, said composition being free from other estrogenic steroids.

6. A composition of mater of claim 5 in which the ratio of tris(hydroxymethyl)aminomethane to alkali metal salt of 8,9-dehydroestrone-3-sulfate is from 1:0.5 to 0.5:1.

7. An alkali metal salt of 8,9-dehydroestrone-3-sulfate ester free from other estrogenic steroids.

8. A salt of claim 7 in which said alkali metal is sodium.

9. A salt of claim 7 in which said alkali metal is potassium.

10. A salt of claim 7 in which said alkali salt is lithium.
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