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Last Updated: April 25, 2024

Claims for Patent: 5,210,081

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Summary for Patent: 5,210,081

Title:	Alkali metal 8,9-dehydroestrone sulfate esters
Abstract:	This invention presents alkali metal salts of 8,9-dehydroestrone, its sulfate ester, and stable compositions thereof, as well as processes for their production. The sulfate ester salts are useful in estrogen replacement therapy.
Inventor(s):	Raveendranath; Panolil C. (Plattsburgh, NY), Wichtowski; John A. (Albans, VT)
Assignee:	American Home Products Corporation (New York, NY)
Application Number:	07/841,694
Patent Claims:	1. A composition of matter consisting essentially of an alkali metal salt of 8,9-dehydroestrone-3-sulfate ester. 2. A composition of matter of claim 1 in which said alkali metal is sodium. 3. A composition of matter of claim 1 in which said alkali metal is potassium. 4. A composition of matter of claim 1 in which said alkali metal is lithium. 5. A composition of matter comprising an alkali metal salt of 8,9-dehydroestrone-3-sulfate in combination with tris(hydroxymethyl)aminomethane, said composition being free from other estrogenic steroids. 6. A composition of mater of claim 5 in which the ratio of tris(hydroxymethyl)aminomethane to alkali metal salt of 8,9-dehydroestrone-3-sulfate is from 1:0.5 to 0.5:1. 7. An alkali metal salt of 8,9-dehydroestrone-3-sulfate ester free from other estrogenic steroids. 8. A salt of claim 7 in which said alkali metal is sodium. 9. A salt of claim 7 in which said alkali metal is potassium. 10. A salt of claim 7 in which said alkali salt is lithium.

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