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Claims for Patent: 5,208,256

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Claims for Patent: 5,208,256

Title: Treatment of ocular hypertension with a synergistic combination for ocular administration
Abstract:A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of (a) a 13,14-dihydro-15-keto-20-loweralkylprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and (b) a polyoxyethylenesorbitan unsaturated higher aliphatic acid monoester in an amount effective in treatment of ocular hypertension.
Inventor(s): Ueno; Ryuji (Hyogo, JP)
Assignee: R-Tech Ueno, Ltd. (Osaka, JP)
Application Number:07/703,660
Patent Claims: 1. A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of

(a) a 13,14-dihydro-15-keto-20-loweralkylprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and

(b) a polyoxyethylenesorbitan unsaturated higher aliphatic acid monoester in an amount effective in treatment of ocular hypertension.

2. The method according to claim 1, in which the component (a) is a 13,14-dihydro-15-keto-20-loweralkylprostaglandin A, B, C, D, E or F, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof.

3. The method according to claim 1, in which the component (a) is a 13,14-dihydro-15-keto-20-ethylprostaglandin A, B, C, D, E or F, or a pharmaceutically acceptable salt thereof, or a lower alkyl ester thereof.

4. The method according to claim 1, in which the component (a) is a 13,14-dihydro-15-keto-20-loweralkylprostaglandin F.sub.2 .alpha. or a pharmaceutically acceptable salt thereof, or a lower alkyl ester thereof.

5. The method according to claim 1, in which the component (a) is a 13,14-dihydro-15-keto-20-ethylprostaglandin F.sub.2 .alpha., or a pharmaceutically acceptable salt thereof, or a lower alkyl ester thereof.

6. The method according to claim 1, in which the component (b) is polyoxyethylenesorbitan monooleate.

7. The method according to claim 1, in which the components (a) and (b) are administered in the ratio (a):(b) of 1:1 to 1:500.

8. The method according to claim 1, in which the components (a) and (b) are administered simultaneously or sequentially.

9. The method of claim 1, wherein glaucoma is treated.

10. A pharmaceutical composition for treatment of ocular hypertension by ocular administration thereof comprising an oculo-hypotensively synergistic combination of

(a) a 13,14-dihydro-15-keto-20-loweralkylprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and

(b) a polyoxyethylenesorbitan unsaturated higher aliphatic acid monoester in association with a pharmaceutically acceptable carrier, diluent or excipient.

11. The pharmaceutical composition according to claim 10, in which the component (a) is a 13,14-dihydro-15-keto-20-ethylprostaglandin F2.alpha., or a pharmaceutically acceptable salt thereof, or a lower alkyl ester thereof, and the component (b) is a polyoxyethylenesorbitan monooleate.
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