.

Deeper Knowledge, Faster

  • Analyze global market entry opportunities
  • Obtain formulation and manufacturing information
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Chinese Patent Office
McKesson
Argus Health
Cipla
Healthtrust
Colorcon
AstraZeneca
Novartis
Fuji
Covington

Generated: November 23, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,206,244

« Back to Dashboard

Claims for Patent: 5,206,244

Title: Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
Abstract:Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
Inventor(s): Zahler; Robert (Pennington, NJ), Slusarchyk; William A. (Skillman, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:07/763,033
Patent Claims: 1. A compound having the formula ##STR101## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is ##STR102## R.sub.4 is alkyl; R.sub.5 is hydrogen, alkyl, substituted alkyl, or aryl; and

R.sub.6 and R.sub.7 are independently hydrogen, --PO.sub.3 H.sub.2, or ##STR103##

2. A compound according to claim 1 wherein R.sub.1 is ##STR104##

3. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or ##STR105##

4. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or --PO.sub.3 H.sub.2.

5. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are hydrogen.

6. A compound according to claim 1 wherein ##STR106##

7. A compound according to claim 1 wherein R.sub.1 is ##STR107##

8. A compound according to claim 1, [1S-(1.alpha.,3.alpha.,4.beta.)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydro xymethyl)-2-methylene-cyclopentyl]-6H-purin-6-one.

9. A compound according to claim 1, [1R-(1.alpha.,3.alpha.,5.beta.)]-3-(6-amino-9H-purin-9-yl)-5-hydroxy-2-met hylenecyclopentanemethanol.

10. An antiviral composition useful for treating herpes simplex virus 1 and 2, varicella zoster virus, and human cytomegalovirus comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula ##STR108## wherein R.sub.1, R.sub.6 and R.sub.7 are as defined in claim 1.

11. A method of treating a herpes simples virus 1, a herpes simplex virus 2, a varicella zoster virus, or a human cytomegalovirus infection in a mammalian species comprising administering an effective amount of the composition of claim 10.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Healthtrust
Boehringer Ingelheim
Julphar
Merck
AstraZeneca
Cantor Fitzgerald
Moodys
Deloitte
Chinese Patent Office

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot