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Claims for Patent: 5,206,244

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Claims for Patent: 5,206,244

Title: Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
Abstract:Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
Inventor(s): Zahler; Robert (Pennington, NJ), Slusarchyk; William A. (Skillman, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:07/763,033
Patent Claims: 1. A compound having the formula ##STR101## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is ##STR102## R.sub.4 is alkyl; R.sub.5 is hydrogen, alkyl, substituted alkyl, or aryl; and

R.sub.6 and R.sub.7 are independently hydrogen, --PO.sub.3 H.sub.2, or ##STR103##

2. A compound according to claim 1 wherein R.sub.1 is ##STR104##

3. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or ##STR105##

4. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or --PO.sub.3 H.sub.2.

5. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are hydrogen.

6. A compound according to claim 1 wherein ##STR106##

7. A compound according to claim 1 wherein R.sub.1 is ##STR107##

8. A compound according to claim 1, [1S-(1.alpha.,3.alpha.,4.beta.)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydro xymethyl)-2-methylene-cyclopentyl]-6H-purin-6-one.

9. A compound according to claim 1, [1R-(1.alpha.,3.alpha.,5.beta.)]-3-(6-amino-9H-purin-9-yl)-5-hydroxy-2-met hylenecyclopentanemethanol.

10. An antiviral composition useful for treating herpes simplex virus 1 and 2, varicella zoster virus, and human cytomegalovirus comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula ##STR108## wherein R.sub.1, R.sub.6 and R.sub.7 are as defined in claim 1.

11. A method of treating a herpes simples virus 1, a herpes simplex virus 2, a varicella zoster virus, or a human cytomegalovirus infection in a mammalian species comprising administering an effective amount of the composition of claim 10.
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