Generated: May 25, 2017
|Title:||Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines|
|Abstract:||Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.|
|Inventor(s):||Zahler; Robert (Pennington, NJ), Slusarchyk; William A. (Skillman, NJ)|
|Assignee:||E. R. Squibb & Sons, Inc. (Princeton, NJ)|
1. A compound having the formula ##STR101## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is ##STR102## R.sub.4 is alkyl; R.sub.5 is hydrogen, alkyl,
substituted alkyl, or aryl; and
R.sub.6 and R.sub.7 are independently hydrogen, --PO.sub.3 H.sub.2, or ##STR103##
2. A compound according to claim 1 wherein R.sub.1 is ##STR104##
3. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or ##STR105##
4. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are independently hydrogen or --PO.sub.3 H.sub.2.
5. A compound according to claim 1 wherein R.sub.6 and R.sub.7 are hydrogen.
6. A compound according to claim 1 wherein ##STR106##
7. A compound according to claim 1 wherein R.sub.1 is ##STR107##
8. A compound according to claim 1, [1S-(1.alpha.,3.alpha.,4.beta.)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydro xymethyl)-2-methylene-cyclopentyl]-6H-purin-6-one.
9. A compound according to claim 1, [1R-(1.alpha.,3.alpha.,5.beta.)]-3-(6-amino-9H-purin-9-yl)-5-hydroxy-2-met hylenecyclopentanemethanol.
10. An antiviral composition useful for treating herpes simplex virus 1 and 2, varicella zoster virus, and human cytomegalovirus comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula ##STR108## wherein R.sub.1, R.sub.6 and R.sub.7 are as defined in claim 1.
11. A method of treating a herpes simples virus 1, a herpes simplex virus 2, a varicella zoster virus, or a human cytomegalovirus infection in a mammalian species comprising administering an effective amount of the composition of claim 10.
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