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Claims for Patent: 5,194,247

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Claims for Patent: 5,194,247

Title: Synergistic skin depigmentation composition
Abstract:There is disclosed a synergistic composition for skin depigmentation with reduced irritation which does not contain a corticosteroid comprising 4-hydroxyanisole and a retinoid, such as all-trans retinoic acid, 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone or (N-acetyl-4-aminophenyl) retinoate, in a pharmaceutically acceptable topical vehicle.
Inventor(s): Nair; Xina (E. Amherst, NY), Tramposch; Kenneth M. (Williamsville, NY)
Assignee:
Application Number:07/554,904
Patent Claims: 1. A synergistic composition for skin depigmentation which does not contain a corticosteroid and which consists essentially of from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight at least one retinoid selected from the group consisting of all-trans retinoic acid, (N-acetyl-4-amino-phenyl) retinoate and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in a pharmaceutically acceptable topical vehicle.

2. A composition as defined in claim 1 wherein said retinoid is all-trans retinoic acid.

3. A composition as defined in claim 2 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01 to 0.1% by weight of all-trans retinoic acid.

4. A composition as defined in claim 1 wherein said retinoid is (N-acetyl-4-aminophenyl) retinoate.

5. A composition as defined in claim 4 containing from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight of (N-acetyl-4-aminophenyl) retinoate.

6. A composition as defined in claim 5 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01 to 0.1% by weight of (N-acetyl-4-aminophenyl) retinoate.

7. A composition as defined in claim 1 wherein said retinoid is 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

8. A composition as defined in claim 7 containing from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight of 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

9. A composition as defined in claim 8 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01 to 0.1% by weight of 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

10. A method depigmenting skin which comprises topically applying to the skin a synergistic composition which does not contain a corticosteroid consisting essentially of from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight at least one retinoid selected from the group consisting of all-trans retinoic acid, (N-acetyl-4-aminophenyl) retinoate and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in a pharmaceutically acceptable topical vehicle.

11. A method as defined in claim 10 wherein said retinoid is all-trans retinoic acid.

12. A method as defined in claim 1 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01% to 0.1% by weight of all-trans retinoic acid.

13. A method as defined in claim 10 wherein said retinoid is (N-acetyl-4-aminophenyl) retinoate.

14. A method as defined in claim 13 wherein said composition contains from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight of (N-acetyl-4-aminophenyl) retinoate.

15. A method as defined in claim 14 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01% to 0.1% by weight of (N-acetyl-4-aminophenyl) retinoate.

16. A method as defined in claim 10 wherein said retinoid is 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

17. A method as defined in claim 16 wherein said composition contains from 0.1% to 5% by weight of 4-hydroxyanisole and from 0.001% to 1% by weight of 11-cis-13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.

18. A method as defined in claim 17 containing from 1 to 2% by weight of 4-hydroxyanisole and from 0.01% to 0.1% by weight of 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone.
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