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Last Updated: December 12, 2025

Claims for Patent: 5,192,741

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Summary for Patent: 5,192,741

Title:	Sustained and controlled release of water insoluble polypeptides
Abstract:	There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.
Inventor(s):	Piero Orsolini, Rolland-Yves Mauvernay, Romano Deghenghi
Assignee:	Debio Recherche Pharmaceutique SA
Application Number:	US07/247,060
Patent Claims:

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