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Claims for Patent: 5,180,715

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Claims for Patent: 5,180,715

Title: Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate
Abstract:The method of treating bladder infections, interstitial cystitis and tumors in mammals which comprises the irrigation of the internal bladder and associated surfaces with an irrigating solution containing an effective amount of sodium pentosanpolysulfate. Also, the treatment of interstitial cystitis by the oral administration of sodium pentosanpolysulfate at high dosages on the order of 200 mg. per day or more.
Inventor(s): Parsons; C. Lowell (San Diego, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Application Number:07/387,402
Patent Claims: 1. A method of treating bladder infections in mammals which comprises irrigating the internal bladder and associated surfaces with an irrigating solution containing an effective amount of sodium pentosanpolysulfate.

2. The method of claim 1 wherein the irrigating solution is saline.

3. The method of claim 1 wherein sodium pentosanpolysulfate is present in the irrigating solution in an amount of from about 1 to 20 mg/ml.

4. The method of claim 1 wherein sodium pentosanpolysulfate is present in the irrigating solution in an amount of from about 5 to 20 mg/ml.

5. A method of treating interstitial cystitis in mammals which comprises irrigating the internal bladder and associated surfaces with an irrigating solution containing an effective amount of sodium pentosanpolysulfate.

6. The method of claim 5 wherein the irrigating solution is saline.

7. The method of claim 5 wherein sodium pentosanpolysulfate is present in the irrigating solution in an amount of from about 1 to 20 mg/ml.

8. The method of claim 5 wherein sodium pentosanpolysulfate is present in the irrigating solution in an amount of from about 5 to 20 mg/ml.

9. A method of treating interstitial cystitis in a mammal which comprises orally administering an effective amount of sodium pentosanpolysulfate to the mammal in need of such treatment.

10. The method of claim 9 wherein at least about 100 mg of sodium pentosanpolysulfate is administered per day.

11. The method of claim 9 wherein about 150 to 300 mg of sodium pentosanpolysulfate is administered per day.
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