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|Title:||Fatty acid terminated polyanhydrides|
|Abstract:||Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fatty acid terminated polyanhydrides. The fatty acid terminated polyanhydrides are also more hydrophobic than the corresponding polyanhydrides that are not terminated with a fatty acid, and combine the properties of thermodynamic and hydrolytic stability, and easy storage. The polymers can be produced with a controlled and low molecular weight. The polyanhydrides are useful in a number of applications, including as a matrix in biodegradable drug delivery systems.|
|Inventor(s):||Domb; Abraham J. (Baltimore, MD), Maniar; Manoj (Baltimore, MD)|
|Assignee:||Nova Pharmaceutical Corporation (Baltimore, MD)|
1. A fatty acid terminated polyanhydride.
2. The fatty acid terminated polyanhydride of claim 1 of the formula: ##STR5## wherein R is an aliphatic, aromatic, or heterocyclic moiety, R' is a linear fatty acid residue of C.sub.6 to C.sub.22, and n is an integer from 1 to 500.
3. The fatty acid terminated polyanhydrides of claim 1 formed by polymerizing fatty acid prepolymers and dicarboxylic acid prepolymers.
4. The fatty acid terminated polyanhydrides of claim 1 wherein the fatty acid is selected from the group consisting of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, heptanoic acid, nonanoic acid, undecanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, heneicosanoic acid, tricosanoic acid, arachidonic acid, docosahexanoic acid, elaidic acid, erucic acid, linoleic acid, linolenic acid, nervonic acid, oleic acid, palmitoleic acid and petriselinic acid.
5. The fatty acid terminated polyanhydrides of claim 1 prepared by polymerization or copolymerization of a dicarboxylic acid selected from the group consisting of HOOC-H.sub.2 C-Y-CH.sub.2 -COOH; aromatic dicarboxylic acids, as defined by the formulas: ##STR6## aromatic-aliphatic dicarboxylic acid, as defined by the formula: ##STR7## aliphatic heterocyclic dicarboxylic acids defined by the formula: ##STR8## wherein X=0, N or S, n=1 to 3; R=R"=an aliphatic, aromatic or heteroaromatic moiety, and Y is a divalent organic radical; aromatic heterocyclic dicarboxylic acids, and aliphatic aromatic heterocyclic dicarboxylic acids; with a fatty acid.
6. The fatty acid terminated polyanhydrides of claim 1 prepared by polymerization or copolymerization of a dicarboxylic acid selected from the group consisting of sebacic acid, phthalic acid, terephthalic acid, isophthalic acid, adipic acid, 1,10-dodecanoic acid, bis(p-carboxyphenoxyalkane), fumaric acid, 1,4-diphenylenediacrylic acid, branched monomers such as 1,3,5-benzenetricarboxylic acid, azeleic acid, pimelic acid, suberic acid (octanedioic acid), itaconic acid, biphenyl-4,4'-dicarboxylic acid, and benzophenone-4,4'-dicarboxylic acid, p-carboxyphenoxyalkanoic acid, hydroquinone-0,0-diacetic acid, 1,4-bis-carboxymethyl benzene, 2,2-bis-(4-hydroxyphenyl)propane-0,0-diacetic acid, 1,4-phenylene-dipropionic acid, and cyclohexane dicarboxylic acid or their anhydrides or acid chlorides with a fatty acid.
7. The fatty acid terminated polyanhydrides of claim 1 prepared by the polymerization of sebacic acid and stearic acid, or their anhydrides or acid chlorides.
8. The fatty acid terminated polyanhydride of claim 1 wherein the fatty acid and the dicarboxylic acid, or their anhydrides or acid chlorides, are combined in a ratio of 2 to 1000 fatty acid units per 500 units of dicarboxylic acid monomers
9. The fatty acid terminated polyanhydride of claim 1 wherein the fatty acid and the dicarboxylic acid are mixed in a ratio of approximately 15% fatty acid prepolymer to approximately 85% dicarboxylic acid prepolymer by weight.
10. The fatty acid terminated polyanhydride polymers of claim 1 wherein the polymers are soluble in organic solvents.
11. The fatty acid terminated polyanhydride polymers of claim 1 wherein the polymers are prepared by melt polycondensation.
12. The fatty acid terminated polyanhydride polymers of claim 1 further comprising a substance to be released from the polyanhydride polymers selected from the group of proteins, carbohydrates, and organic molecules.
13. The fatty acid terminated polyanhydride polymer of claim 12 wherein the substance to be released is selected from the group consisting of chemotherapeutic agents, antibiotics, antivirals, antifungals, antiinflammatories, and anticoagulants.
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