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Claims for Patent: 5,166,207

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Claims for Patent: 5,166,207

Title: Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders
Abstract:A method for enhancing the systemic delivery of dextromethorphan for the treatment of a neurological disorder resulting in injury to nervous tissue, which comprises administering to a patient suffering from the disorder an amount of a cytochrome P450IID6 enzyme inhibitor, sufficient to block dextromethorphan metabolism, and an amount of dextromethorphan sufficient to treat the neurological disorder. Quinidine is particularly suitable for use in the method of the invention.
Inventor(s): Smith; Richard A. (La Jolla, CA)
Assignee: NeuroTherapeutics, Inc. (San Diego, CA)
Application Number:07/717,424
Patent Claims: 1. A method for enhancing the systemic delivery of dextromethorphan for the treatment of a neurological disorder resulting in injury to nervous tissue, which comprises:

administering to a patient suffering from said neurological disorder an amount of a cytochrome P450IID6 enzyme inhibitor, sufficient to block dextromethorphan metabolism, and an amount of dextromethorphan, sufficient to treat said neurological disorder.

2. The method of claim 1, wherein said inhibitor is quinidine.

3. The method of claim 1, wherein said neurological disorder results from ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, Alzheimer's disease, or amyotrophic lateral sclerosis.

4. A method for enhancing the systemic delivery of dextromethorphan for the treatment of a neurological disorder mediated by an endogenous excitatory amino acid, which comprises:

administering to a patient suffering from said neurological disorder an amount of a cytochrome P450IID6 enzyme inhibitor, sufficient to block dextromethorphan metabolism, and an amount of dextromethorphan, sufficient to treat said neurological disorder.

5. The method of claim 4, wherein said inhibitor is quinidine.

6. The method of claim 4, wherein said neurological disorder results from ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, Alzheimer's disease, or amyotrophic lateral sclerosis.
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