Claims for Patent: 5,162,362

Summary for Patent: 5,162,362

Title:	Octahydroindole-2-carboxylic acids
Abstract:	What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.
Inventor(s):	Geiger; Rolf (Frankfurt am Main, DE), Teetz; Volker (Hofheim am Taunus, DE), Urbach; Hansjorg (Kronberg/Taunus, DE), Scholkens; Bernward (Kelkheim, DE), Henning; Rainer (Giessen, DE)
Assignee:	Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:	06/565,887
Patent Claims:	1. A compound of the formula or a physiologically tolerated salt thereof, wherein R.sub.1 is (a) (C.sub.1 -C.sub.6)-alkyl or (b) (C.sub.1 -C.sub.6)-alkyl substituted by 1) (C.sub.5 -C.sub.7)-cycloalkyl 2) amino, 3) (C.sub.1 -C.sub.6)-alkoxycarbonylamino, 4) (C.sub.1 -C.sub.6)-alkanoylamino, or 5) (C.sub.1 -C.sub.6)-alkoxyphenyl; R.sub.2 is (a) (C.sub.1 -C.sub.6)-alkyl, (b) (C.sub.1 -C.sub.6)-alkyl substituted by 1) (C.sub.5 -C.sub.7)-cycloalkyl, 2) phenoxy, 3) phenoxy substituted by 3.1 halogen, 3.2 methyl, or 3.3 methoxy, 4) amino, 5) (C.sub.1 -C.sub.6)-alkylureido, 6) cyclohexylureido, 7) phenylureido, 8) (C.sub.1 -C.sub.6)-alkylmercapto, (C.sub.1 -C.sub.6)-alkylsulfinyl, or (C.sub.1 -C.sub.6)-alkylsulfonyl, 9) phenylmercapto, phenylsulfinyl, or phenylsulfonyl, 10) benzylmercapto, benzylsulfinyl, or benzylsulfonyl, 11) a heterocycle selected from the group consisting of indole, imidazole, pyrrole, pyrazole, thiophene, thiazole, or 12) such a heterocycle substituted by 12.1 halogen, 12.2 methyl, or 12.3 amino; and wherein R.sub.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, or benzyl. 2. A compound as in claim 1 which is N-(1-S-carboethoxy-2-phenoxy-ethyl)-S-alanyl-octahydroindole-2-S-carboxyli c acid. 3. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(3-indolyl)-propyl]-S-alanyl-octahydroindole-2-S-carb oxylic acid. 4. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(3-indolyl)-ethyl]-S-alanyl-octahydroindole-2-S-carbo xylic acid. 5. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(2-thienyl)-propyl]-S-alanyl-octahydroindole-2-S-carb oxylic acid. 6. A compound as in claim 1 which is N-(1-S-carboethoxy-2-phenylthioethyl)-S-alanyl-octahydroindole-2-S-carboxy lic acid. 7. A pharmaceutical preparation for the treatment of hypertension, said preparation comprising a hypotensively effective amount of a compound or salt as in claim 1 and a pharmaceutically acceptable carrier therefor. 8. A method for treating hypertension in a patient suffering therefrom, which method comprises orally, intravenously, or subcutaneously administering to said patient a hypotensively effective amount of a compound as in claim 1.