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Claims for Patent: 5,149,694

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Claims for Patent: 5,149,694

Title: Combination of tobramycin and dexamethasone for topical ophthalmic use
Abstract:Disclosed are pharmaceutical compositions comprising tobramycin and dexamethasone for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.
Inventor(s): Cagle; Gerald D. (Fort Worth, TX), McDonald; Thomas O. (Fort Worth, TX), Rosenthal; Allan L. (Fort Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Application Number:07/440,546
Patent Claims: 1. A method of treating ophthalmic inflammation and infection which comprises administering topically to the affected eye of a human host a therapeutically effective amount of an ophthalmic pharmaceutical composition comprising an anti-inflammatory effective amount of dexamethasone; and anti-infective effective amount of tobramycin; and a pharmaceutically acceptable carrier therefor.

2. A method according to claim 1, wherein the combined concentration of the tobramycin and the dexamethasone is 0.01 to 2.0 percent by weight, and the ratio of the amount of tobramycin to the amount of dexamethasone is in the range of from 0.1:1.0 to 10.0:1.0.

3. A method according to claim 1, wherein the concentration of the tobramycin is 0.3 percent by weight and the concentration of the dexamethasone is 0.1 percent by weight.
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