|Title:||Combination of tobramycin and fluorometholone for topical ophthalmic use|
|Abstract:||Disclosed are pharmaceutical compositions comprising tobramycin and fluorometholone or fluorometholone acetate for topical ophthalmic delivery and methods of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.|
|Inventor(s):||Cagle; Gerald D. (Fort Worth, TX), McDonald; Thomas O. (Fort Worth, TX), Rosenthal; Allan L. (Fort Worth, TX)|
|Assignee:||Alcon Laboratories, Inc. (Fort Worth, TX)|
1. A method of treating ophthalmic inflammation and infection which comprises administering topically to the affected eye of a human host a therapeutically effective amount of
an ophthalmic pharmaceutical composition comprising an anti-inflammatory effective amount of a steroid selected from the group consisting of fluorometholone and fluorometholone acetate; an anti-infective effective amount of tobramycin; and a
pharmaceutically acceptable carrier therefor.
2. A method according to claim 1, wherein the steroid comprises fluorometholone acetate.
3. A method according to claim 1, wherein the ratio of the tobramycin to the steroid is in the range of from 0.1:1.0 to 10.0:1.0.
4. A method according to claim 3, wherein the composition is an aqueous solution; the combined concentration of the tobramycin and the steroid is in the range of 0.01 to 2.0 percent by weight; and the pH of the solution is in the range of 4.5 to 8.0.
5. A method according to claim 4, wherein the steroid comprises fluorometholone acetate.
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