|Title:||Delayed drug delivery device|
|Abstract:||A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.|
|Inventor(s):||Ayer; Atul D. (Mountain View, CA), Theeuwes; Felix (Los Altos, CA), Wong; Patrick S. L. (Hayward, CA)|
|Assignee:||Alza Corporation (Palo Alto, CA)|
1. A dosage form for delivering a beneficial drug formulation to an environment of use, the dosage form comprising:
(a) a wall comprising at least in part a semipermeable composition permeable to the passage of an external fluid present in the environment of use and substantially impermeable to the passage of a beneficial drug formulation, which wall surrounds and forms;
(b) a compartment;
(c) a drug formulation in the compartment that exhibits an osmotic pressure gradient across a semipermeable wall, which drug formulation produces at least one of a physiological, pharmacological, local and systemic effect in an animal;
(d) means for delaying the delivery of the drug formulation up to 12 hours from the compartment, which means comprises a drug-free lamina that surrounds the drug formulation; and,
(e) at least one exit means in the wall for communicating the exterior of the dosage form with the compartment for delivering the dosage formulation from the dosage form.
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