Claims for Patent: 5,135,950

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Summary for Patent: 5,135,950

Title:	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
Abstract:	Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).
Inventor(s):	Aino K. Pippuri, Erkki J. Honkanen, Jorma V. Haarala
Assignee:	Orion Oyj
Application Number:	US07/606,717
Patent Claims:

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