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US Department of Justice
US Army
Federal Trade Commission
Fish and Richardson
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Generated: October 23, 2017

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Claims for Patent: 5,087,454

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Claims for Patent: 5,087,454

Title: Ibuprofen tablet
Abstract:Ibuprofen tablets/caplets formed by wet granulation of the ibuprofen characterized by a dissolution profile maintained stable on aging by incorporating croscarmellose sodium separately into the wet granulation and the compression mix and further incorporating sodium lauryl sulfate into the compression mix.
Inventor(s): Duerholz; Joanne R. (Medford, NJ), DiMaria; Dolores (Vineland, NJ), Blank; Robert G. (Hammonton, NJ)
Assignee: American Home Products Corporation (New York, NY)
Application Number:07/559,862
Patent Claims: 1. In an ibuprofen compressed tablet/caplet containing about 50% to about 70% by weight based on the weight of the tablet/caplet core of ibuprofen formed by (a) wet granulating the ibuprofen with an excipient comprising starch to provide a dry base granulation (b) formulating a compression mix containing the dry base granulation and an excipient comprising starch, and (c) tabletting the compression mix, the improvement which comprises providing a compressed tablet having an improved dissolution profile maintained stable on aging by (1) separately incorporating into each of the wet granulation and the compression mix about 1% to about 2% by weight based on the weight of the compressed tablet core of croscarmellose sodium and (2) incorporating into the compression mix about 0.05 to about 0.15% by weight of the compressed tablet core of sodium lauryl sulfate.
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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Daiichi Sankyo
Express Scripts
Harvard Business School
Argus Health

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