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|Title:||Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid|
|Abstract:||A method of detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin, conjunctives, respiratory, digestive and vaginal mucosa; endometrium and urothelium in which 5-aminolevulinic acid is administered to the patient in an amount sufficient to induce synthesis of protoporphyrin IX in the leisons, followed by exposure of the treated lesion to a photoactivating light in the range 350-640 nm.|
|Inventor(s):||Kennedy; James C. (Kingston, CA), Pottier; Roy H. (Kingston, CA), Reid; Robert L. (Kingston, CA)|
|Assignee:||Queen's University at Kingston (Kingston, CA)|
1. A method for treating malignant and non-malignant tissue abnormalities and lesions of the skin; conjunctiva; respiratory, digestive and vaginal mucosa; endometrium; and
urothelium which are sensitive to protoporphyrin IX in a patient in need thereof comprising administering to said patient an effective amount of 5-aminolevulinic acid so as to induce synthesis of protoporphyrin IX in said lesions, and exposing said
lesions to light within the photoactivating action spectrum of said photoporphyrin IX.
2. A method as claimed in claim 1 wherein said malignant lesions are selected from basal, baso-squamous and squamous carcinomas.
3. A method as claimed in claim 1 wherein said non-malignant lesions are selected from psoriasis and genital warts.
4. A method as claimed in claim 1 wherein said photoactivating light is in the range 350-640 nm.
5. A method as claimed in claim 1 wherein said 5-aminolevulinic acid is administered parenterally.
6. A method as claimed in claim 1 wherein said 5-aminolevulinic acid is administered topically.
7. A method as claimed in claim 1 wherein said 5-aminolevulinic acid is administered orally.
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