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Serving leading biopharmaceutical companies globally:

Baxter
Fish and Richardson
Healthtrust
Daiichi Sankyo
Harvard Business School
US Department of Justice
Deloitte
Colorcon
Moodys
Chubb

Generated: December 11, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,068,249

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Claims for Patent: 5,068,249

Title: Aqueous ranitidine compositions stabilized with ethanol
Abstract:The stability of aqueous formulations of ranitidine or a physiologically acceptable salt thereof is enhanced by the addition of ethanol.
Inventor(s): Long; David R. (Royston, GB2)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:07/494,804
Patent Claims: 1. A pharmaceutical composition which is an aqueous formulation for oral administration of an effective amount of ranitidine and/or one or more physiologically acceptable salts thereof, said formulation comprising a stabilizing effective amount of ethanol and said composition having a pH in the range of 6.5-7.5.

2. A pharmaceutical composition according to claim 1 containing 2.5% to 10% weight/volume ethanol based on the complete formulation.

3. A pharmaceutical composition according to claim 1 containing 7% to 8% weight/volume ethanol based on the complete formulation.

4. A pharmaceutical composition according to claim 1 having a pH in the range 6.8 to 7.4.

5. A pharmaceutical composition according to claim 1 having a pH in the range 7.0 to 7.3.

6. A pharmaceutical composition according to claim 1 wherein said pH is obtained by the use of buffer salts.

7. A pharmaceutical composition according to claim 1 prepared using ranitidine in the form of the hydrochloride salt.

8. A pharmaceutical composition as claimed in claim 1, wherein the effective amount is 20-400 mg ranitidine per 10 ml dose expressed as free base.

9. A pharmaceutical composition as claimed in claim 1, wherein the effective amount is 20-200 mg ranitidine per 10 ml dose expressed as free base.

10. A pharmaceutical composition as claimed in claim 1, wherein the effective amount is 150 mg ranitidine per 10 ml dose expressed as free base.

11. A pharmaceutical composition which is an aqueous formulation of ranitidine suitable for oral administration containing 150 mg ranitidine per 10 ml dose expressed as free base, said formulation having a pH in the range 7.0 to 7.3 and also containing 7% to 8% weight/volume ethanol based on the complete formulation.

12. A pharmaceutical composition according to claim 11 wherein said pH is obtained by the use of buffer salts.
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Serving leading biopharmaceutical companies globally:

Argus Health
Baxter
Fuji
McKinsey
Novartis
Teva
Moodys
Deloitte
Boehringer Ingelheim
Accenture

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