Claims for Patent: 5,053,432

Summary for Patent: 5,053,432

Title:	Naphthoquinone derivatives
Abstract:	Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R1 is hydrogen and R2 is selected from C1-6 alkoxy, aralkoxy, C1-6 alkyl-C1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C1-6 alkyl, halogen and perhalo-C1-6 alkyl; or R1 and R2 are both C1-6 alkyl or phenyl; and n is 0 or 1) and salt thereof. The compounds of formula (I) are useful for the treatment or prophylaxis of protozoal diseases including malaria, theileriosis and coccidiosis. Various processes for preparing compounds of formula (I) are described.
Inventor(s):	Alan T. Hudson, Anthony W. Randall
Assignee:	SmithKline Beecham Corp
Application Number:	US07/456,052
Patent Claims:	1. The trans compound of the formula (I): ##STR14## 2. A physiologically acceptable salt of the trans compound of the formula (I): ##STR15## 3. A method of treating malaria in a human having malaria comprising administering an effective malaria treatment amount of the trans compound of the formula (I): ##STR16## 4. The method of claim 3, in which said compound or salt is administered in a capsule or in a tablet. 5. The method of claim 3, in which said compound or salt is administered by injection. 6. A tablet or capsule containing the trans compound of the formula (I): ##STR17## or a physiologically acceptable salt thereof, said tablet or capsule containing 10 mg to 1 gram of said compound or salt thereof. 7. A parenterial injectable preparation comprising the trans compound of the formula (I): ##STR18## or a physiologically acceptable salt thereof and a pharmaceutically acceptable liquid carrier therefore. 8. A pharmaceutical preparation comprising the trans compound of the formula (I): ##STR19## or a pharmacologically acceptable salt thereof together with a pharmaceutically acceptable carrier therefore.