You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 5,053,407


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 5,053,407
Title: Optically active pyridobenzoxazine derivatives and anti-microbial use
Abstract:An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.
Inventor(s): Hayakawa; Isao (Tokyo, JP), Atarashi; Shohgo (Tokyo, JP), Imamura; Masazumi (Tokyo, JP), Yokohama; Shuichi (Tokyo, JP), Higashihashi; Nobuyuki (Tokyo, JP), Sakano; Katsuichi (Tokyo, JP), Ohshima; Masayuki (Tokyo, JP)
Assignee: Daiichi Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:06/876,623
Patent Claims: 1. An S(-)-pyridobenzoxazine compound represented by the formula (VI) ##STR9## wherein X.sub.1 represents a halogen atom, R.sub.1 represents an alkyl group having 1 to 4 carbon atoms, and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms.

2. S(-)-9-Fluoro-3-methyl-10 -(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxa zine-6-carboxylic acid according to claim 1.

3. S(-)-9-Fluoro-3-methyl-10-(4-ethyl-1-pipe razinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid according to claim 1.

4. A process for treating a patient in need of an antimicrobial therapy which comprises administering to said patient an antimicrobially effective amount of an S(-)-pyridobenzoxazine compound represented by the formula (VI) ##STR10## wherein X.sub.1 represents a halogen atom, R.sub.1 represents an alkyl group having 1 to 4 carbon atoms, and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms.

5. A process for treating a patient in need of an antimicrobial therapy as in claim 4 which comprises administering to said patient an antimicrobially effective amount of S(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-py rido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid.

6. A process for treating a patient in need of an antimicrobial therapy as in claim 4 which comprises administering to said patient an antimicrobially effective amount of S(-)-9-Fluoro-3-methyl-10-(4-ethyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyr ido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.