|Title:|| Epipodophyllotoxin glucoside 4'-phosphate derivatives|
|Abstract:||Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.|
|Inventor(s):|| Saulnier; Mark G. (Middletown, CT), Senter; Peter D. (Seattle, WA), Kadow; John F. (Meriden, CT) |
|Assignee:|| Bristol-Myers Company (New York, NY) |
1. A method for inhibiting mammalian tumor said tumor being sensitive to etoposide or teniposide which comprises administering to a mammal in need thereof an antitumour
effective amount of a compound of the formula ##STR10## wherein R.sup.1 is methyl or 2-thienyl, and R.sup.6 is H; or a pharmaceutically acceptable salt thereof.
2. A method according to claim 1 wherein said compound is etoposide 4'-phosphate disodium salt.