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Generated: December 17, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,041,424

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Claims for Patent: 5,041,424

Title: Epipodophyllotoxin glucoside 4'-phosphate derivatives
Abstract:Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.
Inventor(s): Saulnier; Mark G. (Middletown, CT), Senter; Peter D. (Seattle, WA), Kadow; John F. (Meriden, CT)
Assignee: Bristol-Myers Company (New York, NY)
Application Number:07/450,718
Patent Claims: 1. A method for inhibiting mammalian tumor said tumor being sensitive to etoposide or teniposide which comprises administering to a mammal in need thereof an antitumour effective amount of a compound of the formula ##STR10## wherein R.sup.1 is methyl or 2-thienyl, and R.sup.6 is H; or a pharmaceutically acceptable salt thereof.

2. A method according to claim 1 wherein said compound is etoposide 4'-phosphate disodium salt.
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Dow
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Medtronic

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